Characterization and Detection of Experimental Rat Gliomas Using Magnetic Resonance Imaging

Overview

Journal MAGMA

Publisher Springer

Date 2004 Oct 27

PMID 15503254

Citations 10

Authors

A Vonarbourg

A Sapin

L Lemaire

F Franconi

P Menei

P Jallet

J J Le Jeune

Affiliations

Soon will be listed here.

Abstract

Two different experimental rat brain tumours (F98 glioma and 9L glioma) were characterized using T1 and T2, apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR). Even though both tumours appeared homogenous at the early stage of growth, significant differences were measured for all parametric images between tumours and normal brain tissue. Irrespective of the sequence used, tumour lesion/normal parenchyma contrast for the non-infiltrative 9L was twice that of the infiltrative F98 glioma. The use of spin preparation via an inversion pulse in a fast spin echo sequence increases contrast by a factor of 20-30.

Citing Articles

Emerging MR Imaging and Spectroscopic Methods to Study Brain Tumor Metabolism.

Kumar M, Nanga R, Verma G, Wilson N, Brisset J, Nath K Front Neurol. 2022; 13:789355.

PMID: 35370872 PMC: 8967433. DOI: 10.3389/fneur.2022.789355.

Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness.

Cai K, Tain R, Zhou X, Damen F, Scotti A, Hariharan H Mol Imaging Biol. 2016; 19(2):225-232.

PMID: 27541025 PMC: 5824619. DOI: 10.1007/s11307-016-0995-0.

Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases.

Ainsworth N, McLean M, McIntyre D, Honess D, Brown A, Harden S Magn Reson Med. 2016; 77(5):1987-1995.

PMID: 27279574 PMC: 5412685. DOI: 10.1002/mrm.26257.

Contributors to contrast between glioma and brain tissue in chemical exchange saturation transfer sensitive imaging at 3 Tesla.

Scheidegger R, Wong E, Alsop D Neuroimage. 2014; 99:256-68.

PMID: 24857712 PMC: 4386907. DOI: 10.1016/j.neuroimage.2014.05.036.

A comparison of imaging techniques to monitor tumor growth and cancer progression in living animals.

Puaux A, Ong L, Jin Y, Teh I, Hong M, Chow P Int J Mol Imaging. 2011; 2011:321538.

PMID: 22121481 PMC: 3216304. DOI: 10.1155/2011/321538.

References

Lemaire L, Roullin V, Franconi F, Venier-Julienne M, Menei P, Jallet P . Therapeutic efficacy of 5-fluorouracil-loaded microspheres on rat glioma: a magnetic resonance imaging study. NMR Biomed. 2001; 14(6):360-6. DOI: 10.1002/nbm.720. View

Ikezaki K, Takahashi M, Koga H, Kawai J, Kovacs Z, Inamura T . Apparent diffusion coefficient (ADC) and magnetization transfer contrast (MTC) mapping of experimental brain tumor. Acta Neurochir Suppl. 1997; 70:170-2. DOI: 10.1007/978-3-7091-6837-0_52. View

Parizel P, Degryse H, Gheuens J, Martin J, Van Vyve M, De La Porte C . Gadolinium-DOTA enhanced MR imaging of intracranial lesions. J Comput Assist Tomogr. 1989; 13(3):378-85. DOI: 10.1097/00004728-198905000-00002. View

Chenevert T, McKeever P, Ross B . Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. Clin Cancer Res. 1998; 3(9):1457-66. View

Quesson B, Bouzier A, Thiaudiere E, Delalande C, Merle M, Canioni P . Magnetization transfer fast imaging of implanted glioma in the rat brain at 4.7 T: interpretation using a binary spin-bath model. J Magn Reson Imaging. 1997; 7(6):1076-83. DOI: 10.1002/jmri.1880070621. View

Damadian R . Tumor detection by nuclear magnetic resonance. Science. 1971; 171(3976):1151-3. DOI: 10.1126/science.171.3976.1151. View

Dzik-Jurasz A, Domenig C, George M, Wolber J, Padhani A, Brown G . Diffusion MRI for prediction of response of rectal cancer to chemoradiation. Lancet. 2002; 360(9329):307-8. DOI: 10.1016/S0140-6736(02)09520-X. View

Kauppinen R . Monitoring cytotoxic tumour treatment response by diffusion magnetic resonance imaging and proton spectroscopy. NMR Biomed. 2002; 15(1):6-17. DOI: 10.1002/nbm.742. View

Lemaire L, Franconi F, Saint-Andre J, Roullin V, Jallet P, Le Jeune J . High-field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour. NMR Biomed. 2000; 13(3):116-23. DOI: 10.1002/1099-1492(200005)13:3<116::aid-nbm616>3.0.co;2-d. View

10.

Zhao M, Pipe J, BONNETT J, Evelhoch J . Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo. Br J Cancer. 1996; 73(1):61-4. PMC: 2074297. DOI: 10.1038/bjc.1996.11. View

11.

Rajan S, ROSA L, Francisco J, Muraki A, Carvlin M, Tuturea E . MRI characterization of 9L-glioma in rat brain at 4.7 Tesla. Magn Reson Imaging. 1990; 8(2):185-90. DOI: 10.1016/0730-725x(90)90252-w. View

12.

Wilmes L, Els T, Bockhorst K, Eis M, Bonnekoh P, Hossmann K . In vivo relaxometry of three brain tumors in the rat: effect of Mn-TPPS, a tumor-selective contrast agent. J Magn Reson Imaging. 1993; 3(1):5-12. DOI: 10.1002/jmri.1880030103. View

13.

Lemaire L, Howe F, Rodrigues L, Griffiths J . Assessment of induced rat mammary tumour response to chemotherapy using the apparent diffusion coefficient of tissue water as determined by diffusion-weighted 1H-NMR spectroscopy in vivo. MAGMA. 1999; 8(1):20-6. DOI: 10.1007/BF02590631. View

14.

Raila F, Bowles Jr A, Perkins E, Terrell A . Sequential imaging and volumetric analysis of an intracerebral C6 glioma by means of a clinical MRI system. J Neurooncol. 1999; 43(1):11-7. DOI: 10.1023/a:1006285800794. View

15.

Eis M, Els T, Hossmann K . Quantitative diffusion MR imaging of cerebral tumor and edema. Acta Neurochir Suppl (Wien). 1994; 60:344-6. DOI: 10.1007/978-3-7091-9334-1_92. View

16.

Steen R, Gronemeyer S, Kingsley P, Reddick W, Langston J, Taylor J . Precise and accurate measurement of proton T1 in human brain in vivo: validation and preliminary clinical application. J Magn Reson Imaging. 1994; 4(5):681-91. DOI: 10.1002/jmri.1880040511. View

17.

Eis M, Els T . High resolution quantitative relaxation and diffusion MRI of three different experimental brain tumors in rat. Magn Reson Med. 1995; 34(6):835-44. DOI: 10.1002/mrm.1910340608. View