Lack of Hepatocyte Involvement in the Genesis of the Sinusoidal Dilatation Related to Heroin Addiction: a Morphometric Study

Overview

Journal Virchows Arch A Pathol Anat Histopathol

Specialty Anatomy & Histology

Date 1992 Jan 1

PMID 1549903

Citations 3

Authors

M S Trigueiro de Araujo

F Gerard

P Chossegros

S Guerret

J A Grimaud

Affiliations

Soon will be listed here.

Abstract

A histological and morphometric study demonstrated a relationship between vascular changes in the hepatic lobule and heroin consumption. To establish the role of hepatocytes in the genesis of sinusoidal dilatation, morphometric analysis was performed on ten drug abusers and eight controls. A total of 1800 hepatocytes, in 67 centrilobular areas, were analysed from biopsies from the total patient number. Computerized results of hepatocyte surface area, perimeter, maximum linear dimension and minimum linear dimension demonstrated no statistically significant difference for these variables, particularly for hepatocyte surface area (Controls: 268.66 +/- 95.25; drug abusers: 252.00 +/- 78.94, p = 0.24), when the two groups of patients were compared. Hepatocyte morphology at the time of the biopsy was unaltered, although transaminase values were elevated for all drug abusers. It is, therefore, possible that the hepatocytes were not implicated in the pathogenesis of sinusoidal dilatation. This suggestion supports our previous results, which suggested that heroin was capable of inducing direct vascular hepatotoxicity.

Citing Articles

Beneficial effects of Bacopa monnieri extract on opioid induced toxicity.

Shahid M, Subhan F, Ullah I, Ali G, Alam J, Shah R Heliyon. 2016; 2(2):e00068.

PMID: 27441247 PMC: 4945900. DOI: 10.1016/j.heliyon.2016.e00068.

Ultrastructural changes in the liver of intravenous heroin addicts.

Ilic G, Karadzic R, Kostic-Banovic L, Stojanovic J, Antovic A Bosn J Basic Med Sci. 2010; 10(1):38-43.

PMID: 20192929 PMC: 5596609. DOI: 10.17305/bjbms.2010.2730.

Cellular and matrix changes in drug abuser liver sinusoids: a semiquantitative and morphometric ultrastructural study.

Trigueiro de Araujo M, Gerard F, Chossegros P, Guerret S, Barlet P, Adeleine P Virchows Arch A Pathol Anat Histopathol. 1993; 422(2):145-52.

PMID: 8465514 DOI: 10.1007/BF01607166.

References

Nagamatsu K, Ohno Y, IKEBUCHI H, Takahashi A, Terao T, Takanaka A . Morphine metabolism in isolated rat hepatocytes and its implications for hepatotoxicity. Biochem Pharmacol. 1986; 35(20):3543-8. DOI: 10.1016/0006-2952(86)90624-6. View

Scoazec J, Marche C, Girard P, Houtmann J, Saimot A, Benhamou J . Peliosis hepatis and sinusoidal dilation during infection by the human immunodeficiency virus (HIV). An ultrastructural study. Am J Pathol. 1988; 131(1):38-47. PMC: 1880584. View

Kunze K, Porst H, Lohmann J, Tschopel L . [Liver lesions induced by dihydralazine and propranolol]. Zentralbl Allg Pathol. 1985; 130(1):19-29. View

POTTER Jr H, COHEN N, Norris R . Chronic hepatic dysfunction in heroin addicts. Possible relation to carrier state of viral hepatitis. JAMA. 1960; 174:2049-51. DOI: 10.1001/jama.1960.03030160035008. View

Schmidt G, Borsch G, Ricken D, Muller K, Neuberger J . [Centrolobular liver cell necroses following occupational halothane contact. Association with antibodies to halothane altered liver cell components]. Z Gastroenterol. 1985; 23(4):192-7. View

ROSCHLAU G . [Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases]. Zentralbl Allg Pathol. 1983; 127(5-6):385-93. View

de Araujo M, Gerard F, Chossegros P, Porto L, Barlet P, Grimaud J . Vascular hepatotoxicity related to heroin addiction. Virchows Arch A Pathol Anat Histopathol. 1990; 417(6):497-503. DOI: 10.1007/BF01625730. View

Davion T, Capron J, Andrejak M, Geoffroy P, QUENUM C . [Acute hepatitis due to carbamazepine (Tegretol). Study of a case and review of the literature]. Gastroenterol Clin Biol. 1984; 8(1):52-6. View

WAY E, KEMP J, Young J, GRASSETTI D . The pharmacologic effects of heroin in relationship to its rate of biotransformation. J Pharmacol Exp Ther. 1960; 129:144-54. View

10.

Gomez-Lechon M, Ponsoda X, Jover R, Fabra R, Trullenque R, Castell J . Hepatotoxicity of the opioids morphine, heroin, meperidine, and methadone to cultured human hepatocytes. Mol Toxicol. 1987; 1(4):453-63. View

11.

Sawynok J . The therapeutic use of heroin: a review of the pharmacological literature. Can J Physiol Pharmacol. 1986; 64(1):1-6. DOI: 10.1139/y86-001. View

12.

ELLIOTT H, Parker K, Wright J, NOMOF N . Actions and metabolism of heroin administered by continuous intravenous infusion to man. Clin Pharmacol Ther. 1971; 12(5):806-14. DOI: 10.1002/cpt1971125806. View

13.

James R, Goodman D, Harbison R . Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics. J Pharmacol Exp Ther. 1982; 221(3):708-14. View

14.

Chang Y, Ho I . Effects of acute and continuous morphine administration on serum glutamate oxalacetate transaminase and glutamate pyruvate transaminase activities in the mouse. Biochem Pharmacol. 1979; 28(8):1373-7. DOI: 10.1016/0006-2952(79)90440-4. View

15.

Wisse E, De Zanger R, Charels K, Van Der Smissen P, McCuskey R . The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology. 1985; 5(4):683-92. DOI: 10.1002/hep.1840050427. View

16.

Moldeus P, Orrenius S . On the mechanisms of glutathione depletion in hepatocytes exposed to morphine and ethylmorphine. Toxicology. 1986; 42(1):13-21. DOI: 10.1016/0300-483x(86)90088-0. View

17.

Skoulis N, James R, Harbison R, Roberts S . Depression of hepatic glutathione by opioid analgesic drugs in mice. Toxicol Appl Pharmacol. 1989; 99(1):139-47. DOI: 10.1016/0041-008x(89)90119-1. View

18.

Gorodetzky C, SAPIRA J, Jasinski D, Martin W . Liver disease in narcotic addicts. I. The role of the drug. Clin Pharmacol Ther. 1968; 9(6):720-4. DOI: 10.1002/cpt196896720. View

19.

Czapar C, Moore D, Rhone D . Peliosis hepatis in the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1986; 110(7):611-3. View

20.

Bagheri S, Boyer J . Peliosis hepatis associated with androgenic-anabolic steroid therapy. A severe form of hepatic injury. Ann Intern Med. 1974; 81(5):610-8. DOI: 10.7326/0003-4819-81-5-610. View