Article: Invasive aspergillosis complicated by subclavian artery occlusion and costal osteomyelitis after autologous bone marrow transplantation

A 47 year old woman presented with invasive pulmonary aspergillosis complicated by subclavian artery occlusion and rib fracture due to fungal osteomyelitis. This followed persistent pancytopenia resulting from autologous bone marrow transplantation for metastatic breast cancer.

Citing Articles

Aspergillus spp. osteoarticular infections: an updated systematic review on the diagnosis, treatment and outcomes of 186 confirmed cases.

Tsantes A, Papadopoulos D, Markou E, Zarokostas K, Sokou R, Trikoupis I Med Mycol. 2022; 60(8).

PMID: 35867975 PMC: 9849853. DOI: 10.1093/mmy/myac052.

Disseminated Aspergillus flavus following septic arthritis in an immunocompetent patient: a case report.

Tiwari V, Khatri K, Khan S, Nath D BMC Res Notes. 2014; 7:709.

PMID: 25301635 PMC: 4200168. DOI: 10.1186/1756-0500-7-709.

Aspergillus fumigatus empyema, arthritis, and calcaneal osteomyelitis in a lung transplant patient successfully treated with posaconazole.

Lodge B, Ashley E, Steele M, Perfect J J Clin Microbiol. 2004; 42(3):1376-8.

PMID: 15004125 PMC: 356879. DOI: 10.1128/JCM.42.3.1376-1378.2004.

Phase II study of intensive chemotherapy with autologous bone marrow transplantation in patients in complete remission of disseminated breast cancer.

De Vries E, Rodenhuis S, Schouten H, Hupperets P, Dolsma W, Lebesque J Breast Cancer Res Treat. 1996; 39(3):307-13.

PMID: 8877010 DOI: 10.1007/BF01806158.

References

1.

Kirk Jr J, Greenfield R, Slease R, EPSTEIN R . Analysis of early infectious complications after autologous bone marrow transplantation. Cancer. 1988; 62(11):2445-50. DOI: 10.1002/1097-0142(19881201)62:11<2445::aid-cncr2820621133>3.0.co;2-i. View

2.

Byard R, JIMENEZ C, Carpenter B, Hsu E . Aspergillus-related aortic thrombosis. CMAJ. 1987; 136(2):155-6. PMC: 1491984. View

3.

Barnwell P, Jelsma L, Raff M . Aspergillus osteomyelitis. Report of a case and review of the literature. Diagn Microbiol Infect Dis. 1985; 3(6):515-9. DOI: 10.1016/s0732-8893(85)80008-0. View

4.

Anderson J, Kron I . Treatment of Aspergillus infection of the proximal aortic prosthetic graft with associated vertebral osteomyelitis. J Vasc Surg. 1984; 1(4):579-81. DOI: 10.1067/mva.1984.avs0010579. View

5.

Tack K, Rhame F, Brown B, THOMPSON Jr R . Aspergillus osteomyelitis. Report of four cases and review of the literature. Am J Med. 1982; 73(2):295-300. DOI: 10.1016/0002-9343(82)90192-9. View

6.

GARTENBERG G, Einstein K, Jagirdar J . Superior vena cava syndrome caused by invasive aspergillosis. Chest. 1978; 74(6):671-2. DOI: 10.1378/chest.74.6.671. View

7.

Denning D, Stevens D . Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. Rev Infect Dis. 1990; 12(6):1147-201. DOI: 10.1093/clinids/12.6.1147. View

8.

Shapiro M, Albelda S, MAYOCK R, McLean G . Severe hemoptysis associated with pulmonary aspergilloma. Percutaneous intracavitary treatment. Chest. 1988; 94(6):1225-31. DOI: 10.1378/chest.94.6.1225. View

9.

Burch P, Karp J, Merz W, Kuhlman J, Fishman E . Favorable outcome of invasive aspergillosis in patients with acute leukemia. J Clin Oncol. 1987; 5(12):1985-93. DOI: 10.1200/JCO.1987.5.12.1985. View

10.

Rinaldi M . Invasive aspergillosis. Rev Infect Dis. 1983; 5(6):1061-77. DOI: 10.1093/clinids/5.6.1061. View

11.

Davey P . New antiviral and antifungal drugs. BMJ. 1990; 300(6727):793-8. PMC: 1662554. DOI: 10.1136/bmj.300.6727.793. View

12.

Jeyasingham K . Limited thoracoplasty in the management of complicated pulmonary aspergillomas. Thorax. 1989; 44(12):1027-30. PMC: 1020879. DOI: 10.1136/thx.44.12.1027. View

Invasive Aspergillosis Complicated by Subclavian Artery Occlusion and Costal Osteomyelitis After Autologous Bone Marrow Transplantation