A New Translocation T(9;11)(q34;p15) Fuses NUP98 to a Novel Homeobox Partner Gene, PRRX2, in a Therapy-related Acute Myeloid Leukemia

Overview

Journal Leukemia

Specialties Hematology
Oncology

Date 2004 Oct 22

PMID 15496970

Citations 9

Authors

C Gervais

L Mauvieux

N Perrusson

C Helias

S Struski

V Leymarie

B Lioure

M Lessard

Affiliations

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Citing Articles

Rare Non-Cryptic Rearrangements Associated With Myeloid Neoplasms and Their Poor Prognostic Impact.

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NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities.

Rasouli M, Troester S, Grebien F, Goemans B, Zwaan C, Heidenreich O Hemasphere. 2024; 8(9):e70013.

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Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies.

Michmerhuizen N, Klco J, Mullighan C Blood. 2020; 136(20):2275-2289.

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PRRX-NCOA1/2 rearrangement characterizes a distinctive fibroblastic neoplasm.

Lacambra M, Weinreb I, Demicco E, Chow C, Sung Y, Swanson D Genes Chromosomes Cancer. 2019; 58(10):705-712.

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Statistical algorithms improve accuracy of gene fusion detection.

Hsieh G, Bierman R, Szabo L, Lee A, Freeman D, Watson N Nucleic Acids Res. 2017; 45(13):e126.

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References

Lam D, Aplan P . NUP98 gene fusions in hematologic malignancies. Leukemia. 2001; 15(11):1689-95. DOI: 10.1038/sj.leu.2402269. View

Nakamura T, Yamazaki Y, Hatano Y, Miura I . NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). Blood. 1999; 94(2):741-7. View

Nakamura T, Largaespada D, Lee M, Johnson L, Ohyashiki K, Toyama K . Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet. 1996; 12(2):154-8. DOI: 10.1038/ng0296-154. View

Norris R, Scott K, Moore C, Stetten G, Brown C, Jabs E . Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. Mamm Genome. 2000; 11(11):1000-5. DOI: 10.1007/s003350010193. View

Ten Berge D, Brouwer A, Korving J, Reijnen M, van Raaij E, Verbeek F . Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development. 2001; 128(15):2929-38. DOI: 10.1242/dev.128.15.2929. View