Recirculation of Lymphocyte Subsets (CD5+, CD4+, CD8+, SBU-T19+ and B Cells) Through Gut and Peripheral Lymph Nodes

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1989 Jan 1

PMID 15493265

Citations 2

Authors

W G Kimpton

E A Washington

R N Cahill

Affiliations

Soon will be listed here.

Abstract

The surface phenotypes (CD5+, CD4+, CD8+, SBU-T19+, MHC class II+, T80+ and sIg+) of lymphocytes in blood, and in prescapular and ileocaecal efferent lymph of sheep, have been determined. The similarity in the distribution of lymphocyte subsets in both lymph compartments indicated that the non-random migration of lymphocyte populations to peripheral lymph nodes and gut could not be due to preferential migration of a particular lymphocyte subset such as CD4+ or CD8+ cells to one tissue. Marked differences in the percentage of lymphocyte subsets between blood and efferent lymph suggested that some lymphocyte subsets leave the blood with differing efficiencies and that differential extraction of lymphocyte subsets from blood by a lymph node may be due to subset-specific lymphocyte-endothelial interactions.

Citing Articles

Characterisation of ovine lymphatic vessels in fresh specimens.

Yen H, Murray C, Washington E, Kimpton W, Davies H PLoS One. 2019; 14(1):e0209414.

PMID: 30650093 PMC: 6334992. DOI: 10.1371/journal.pone.0209414.

Production of cytokines by lymphocytes from spleen, mesenteric lymph node and intestinal lamina propria of pigs.

Bailey M, Hall L, Bland P, Stokes C Immunology. 1994; 82(4):577-83.

PMID: 7835920 PMC: 1414927.

References

Scollay R, Hopkins J, Hall J . Possible role of surface Ig in non-random recirculation of small lymphocytes. Nature. 1976; 260(5551):528-9. DOI: 10.1038/260528a0. View

Scollay R, Hall J, ORLANS E . Studies on the lymphocytes of sheep. II. Some properties of cells in various compartments of the recirculating lymphocyte pool. Eur J Immunol. 1976; 6(2):121-5. DOI: 10.1002/eji.1830060210. View

Hay J, Hobbs B . The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response. J Exp Med. 1977; 145(1):31-44. PMC: 2180596. DOI: 10.1084/jem.145.1.31. View

Cahill R, Poskitt D, Frost D, TRNKA Z . Two distinct pools of recirculating T lymphocytes: migratory characteristics of nodal and intestinal T lymphocytes. J Exp Med. 1977; 145(2):420-8. PMC: 2180614. DOI: 10.1084/jem.145.2.420. View

Hall J, Hopkins J, ORLANS E . Studies on the lymphocytes of sheep. III. Destination of lymph-borne immunoblasts in relation to their tissue of origin. Eur J Immunol. 1977; 7(1):30-7. DOI: 10.1002/eji.1830070108. View

Miller H, Adams E . Reassortment of lymphocytes in lymph from normal and allografted sheep. Am J Pathol. 1977; 87(1):59-80. PMC: 2032066. View

Evans R, Faldetta T, Humphreys R, Pratt D, Yunis E, Schlossman S . Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens. J Exp Med. 1978; 148(5):1440-5. PMC: 2185039. DOI: 10.1084/jem.148.5.1440. View

Hall J . An essay on lymphocyte circulation and the gut. Monogr Allergy. 1980; 16:100-11. View

Chin W, Hay J . A comparison of lymphocyte migration through intestinal lymph nodes, subcutaneous lymph nodes, and chronic inflammatory sites of sheep. Gastroenterology. 1980; 79(6):1231-42. View

10.

Miyasaka M, Heron I, Dudler L, Cahill R, Forni L, Knaak T . Studies on the differentiation of T lymphocytes in sheep. I. Recognition of a sheep T-lymphocyte differentiation antigen by a monoclonal antibody T-80. Immunology. 1983; 49(3):545-53. PMC: 1454302. View

11.

Heitmann H . [A method for the long-term collection of efferent lymph from the superficial cervical node in sheep]. Zentralbl Veterinarmed A. 1970; 17(6):517-26. View

12.

Smith J, McIntosh G, Morris B . The migration of cells through chronically inflamed tissues. J Pathol. 1970; 100(1):21-9. DOI: 10.1002/path.1711000104. View

13.

Ford W, Simmonds S . The tempo of lymphocyte recirculation from blood to lymph in the rat. Cell Tissue Kinet. 1972; 5(2):175-89. DOI: 10.1111/j.1365-2184.1972.tb01014.x. View

14.

Scollay R, Lafferty K . Differences in the graft-versus-host reactivity of cells migrating through nonlymphoid tissue or lymph nodes. Transplantation. 1975; 19(2):170-6. DOI: 10.1097/00007890-197502000-00010. View

15.

Cahill R, Frost H, TRNKA Z . The effects of antigen on the migration of recirculating lymphocytes through single lymph nodes. J Exp Med. 1976; 143(4):870-88. PMC: 2190155. DOI: 10.1084/jem.143.4.870. View

16.

Reynolds J, Morris B . The evolution and involution of Peyer's patches in fetal and postnatal sheep. Eur J Immunol. 1983; 13(8):627-35. DOI: 10.1002/eji.1830130805. View

17.

BLUE M, Daley J, Levine H, Schlossman S . Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry. J Immunol. 1985; 134(4):2281-6. View

18.

Rasmussen R, Chin Y, Woodruff J, Easton T . Lymphocyte recognition of lymph node high endothelium. VII. Cell surface proteins involved in adhesion defined by monoclonal anti-HEBFLN (A.11) antibody. J Immunol. 1985; 135(1):19-24. View

19.

Mackay C, Maddox J, Brandon M . Characterization of two sheep lymphocyte differentiation antigens, SBU-T1 and SBU-T6. Immunology. 1985; 55(4):729-37. PMC: 1453766. View

20.

Maddox J, Mackay C, Brandon M . Surface antigens, SBU-T4 and SBU-T8, of sheep T lymphocyte subsets defined by monoclonal antibodies. Immunology. 1985; 55(4):739-48. PMC: 1453767. View