Why is Transcription Coupled to Translation in Bacteria?

Overview

Journal Mol Microbiol

Specialties Microbiology
Molecular Biology

Date 2004 Oct 20

PMID 15491353

Citations 72

Authors

J Gowrishankar

R Harinarayanan

Affiliations

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Abstract

Active mechanisms exist to prevent transcription that is uncoupled from translation in the protein-coding genes of bacteria, as exemplified by the phenomenon of nonsense polarity. Bacterial transcription-translation coupling may be viewed as one among several co-transcriptional processes, including those for mRNA processing and export in the eukaryotes, that operate in the various life forms to render the nascent transcript unavailable for formation of otherwise deleterious R-loops in the genome.

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