[Novel Calcium Phosphate Formula for Filling Bone Defects. Initial in Vivo Long-term Results]

Overview

Journal Mund Kiefer Gesichtschir

Specialties Dentistry
General Surgery

Date 2004 Oct 14

PMID 15480868

Citations 3

Authors

K-O Henkel

Th Gerber

W Dietrich

V Bienengraber

Affiliations

Soon will be listed here.

Abstract

Background: Up to now hydroxyapatite (HA) and beta-tricalciumphosphate (beta-TCP) ceramics have been routinely sintered at temperatures between 1100 degrees and 1500 degrees C. Our new calcium ceramic is fabricated by a sol-gel process at 200 degrees C. The aim of this investigation was to test the biodegradation of and the induction of bone formation by this material.

Material And Methods: Eighteen 1-year-old Goettingen minipigs were divided into three groups. Critical size defects (>5 cm(3)) in the mandible were treated differently in all three animals (group 1: filling with 40% beta-TCP plus 60% HA, group 2: pure HA was applied, group 3 served as controls: only gelatinous material was given). Macroscopic and microscopic investigations of the former defects were made 8 months postoperatively. RESULTS. In groups 1 and 2 biodegradation of more than 93% of the new calcium phosphate formula was found 8 months postoperatively and considered to be very good. No difference was observed between pure HA (group 2) and the combination of HA and beta-TCP (group 1). In both groups complete bone formation was seen macroscopically in the former defects. In the control group only incomplete bone formation with 48.4% of the defect area was noted. This difference was significant ( p<0.001).

Discussion: The new calcium phosphate formula made by a sol-gel method at 120 degrees C seems to be suitable for filling bone defects and is of interest for orthopedic surgery, traumatology, craniomaxillofacial surgery, and dentistry.

Citing Articles

Investigation of a pre-clinical mandibular bone notch defect model in miniature pigs: clinical computed tomography, micro-computed tomography, and histological evaluation.

Carlisle P, Guda T, Silliman D, Lien W, Hale R, Brown Baer P J Korean Assoc Oral Maxillofac Surg. 2016; 42(1):20-30.

PMID: 26904491 PMC: 4761569. DOI: 10.5125/jkaoms.2016.42.1.20.

Biomaterials for craniofacial reconstruction.

Neumann A, Kevenhoerster K GMS Curr Top Otorhinolaryngol Head Neck Surg. 2011; 8:Doc08.

PMID: 22073101 PMC: 3199817. DOI: 10.3205/cto000060.

[Resorbable bone substitution materials: An overview of commercially available materials and new approaches in the field of composites].

Heinemann S, Gelinsky M, Worch H, Hanke T Orthopade. 2011; 40(9):761-73.

PMID: 21424299 DOI: 10.1007/s00132-011-1748-z.

References

Koshino T, Murase T, Takagi T, Saito T . New bone formation around porous hydroxyapatite wedge implanted in opening wedge high tibial osteotomy in patients with osteoarthritis. Biomaterials. 2001; 22(12):1579-82. DOI: 10.1016/s0142-9612(00)00318-5. View

Artzi Z, Nemcovsky C, Tal H, Dayan D . Histopathological morphometric evaluation of 2 different hydroxyapatite-bone derivatives in sinus augmentation procedures: a comparative study in humans. J Periodontol. 2001; 72(7):911-20. DOI: 10.1902/jop.2001.72.7.911. View

Petite H, Viateau V, Bensaid W, Meunier A, de Pollak C, Bourguignon M . Tissue-engineered bone regeneration. Nat Biotechnol. 2000; 18(9):959-63. DOI: 10.1038/79449. View

Pistner H, Reuther J, Reinhart E, Kubler N, Priessnitz B . [New hydroxylapatite cement for craniofacial surgery]. Mund Kiefer Gesichtschir. 1998; 2 Suppl 1:S37-40. DOI: 10.1007/PL00014476. View

Jensen S, Aaboe M, Pinholt E, Hjorting-Hansen E, Melsen F, Ruyter I . Tissue reaction and material characteristics of four bone substitutes. Int J Oral Maxillofac Implants. 1996; 11(1):55-66. View

Henkel K, Gerber T, Dorfling P, Hartel J, Jonas L, Gundlach K . [Stimulating regeneration of bone defects by implantation of bioceramics and autologous osteoblast transplantation]. Mund Kiefer Gesichtschir. 2002; 6(2):59-65. DOI: 10.1007/s10006-001-0340-9. View

Heymann D, Delecrin J, Deschamps C, Gouin F, Padrines M, Passuti N . [In vitro assessment of combining osteogenic cells with macroporous calcium-phosphate ceramics]. Rev Chir Orthop Reparatrice Appar Mot. 2001; 87(1):8-17. View

Osborn J, Donath K . [Endosseous implantation of hydroxylapatite ceramics and tricalcium phosphate ceramic: integration versus substitution]. Dtsch Zahnarztl Z. 1984; 39(12):970-6. View

Hing K, Best S, Tanner K, Bonfield W, Revell P . Biomechanical assessment of bone ingrowth in porous hydroxyapatite. J Mater Sci Mater Med. 2004; 8(12):731-6. DOI: 10.1023/a:1018500309969. View

10.

Piesold J, Merwald M, Braxein K, Pistner H . [Rapid setting calcium phosphate cement for craniomaxillofacial surgery. 6 years experience]. Mund Kiefer Gesichtschir. 2004; 8(1):5-11. DOI: 10.1007/s10006-003-0510-z. View

11.

van Steenberghe D, Callens A, Geers L, Jacobs R . The clinical use of deproteinized bovine bone mineral on bone regeneration in conjunction with immediate implant installation. Clin Oral Implants Res. 2001; 11(3):210-6. DOI: 10.1034/j.1600-0501.2000.011003210.x. View

12.

Vuola J, Taurio R, Goransson H, Asko-Seljavaara S . Compressive strength of calcium carbonate and hydroxyapatite implants after bone-marrow-induced osteogenesis. Biomaterials. 1998; 19(1-3):223-7. DOI: 10.1016/s0142-9612(97)00211-1. View

13.

Sailer H, Weber F . [Bone substitutes]. Mund Kiefer Gesichtschir. 2000; 4 Suppl 1:S384-91. DOI: 10.1007/PL00014562. View

14.

Gunther K, Scharf H, Pesch H, Puhl W . [Integration properties of bone substitute materials. Experimental studies on animals]. Orthopade. 1998; 27(2):105-17. DOI: 10.1007/s001320050208. View

15.

Weibrich G, Gnoth S, Kunkel M, Trettin R, WERNER H, Wagner W . [Roentgen spectrometry comparison of currently available bone substitutes]. Mund Kiefer Gesichtschir. 1999; 3(2):92-7. DOI: 10.1007/s100060050103. View

16.

Yuan H, Yang Z, De Bruij J, de Groot K, Zhang X . Material-dependent bone induction by calcium phosphate ceramics: a 2.5-year study in dog. Biomaterials. 2001; 22(19):2617-23. DOI: 10.1016/s0142-9612(00)00450-6. View

17.

Ragel C, Vallet-Regi M, Rodriguez-Lorenzo L . Preparation and in vitro bioactivity of hydroxyapatite/solgel glass biphasic material. Biomaterials. 2002; 23(8):1865-72. DOI: 10.1016/s0142-9612(01)00313-1. View

18.

Gauthier O, Bouler J, Aguado E, Pilet P, Daculsi G . Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth. Biomaterials. 1998; 19(1-3):133-9. DOI: 10.1016/s0142-9612(97)00180-4. View