Open Mass Spectrometry Search Algorithm

Overview

Journal J Proteome Res

Publisher American Chemical Society

Specialty Biochemistry

Date 2004 Oct 12

PMID 15473683

Citations 654

Authors

Lewis Y Geer

Sanford P Markey

Jeffrey A Kowalak

Lukas Wagner

Ming Xu

Dawn M Maynard

Xiaoyu Yang

Wenyao Shi

Stephen H Bryant

Affiliations

Soon will be listed here.

Abstract

Large numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spectrometry Search Algorithm (OMSSA), specificity is calculated by a classic probability score using an explicit model for matching experimental spectra to sequences. At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets.

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