Phylogeny of Mitochondrial DNA Macrohaplogroup N in India, Based on Complete Sequencing: Implications for the Peopling of South Asia

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2004 Oct 7

PMID 15467980

Citations 128

Authors

Malliya Gounder Palanichamy

Chang Sun

Suraksha Agrawal

Hans-Jurgen Bandelt

Qing-Peng Kong

Faisal Khan

Cheng-Ye Wang

Tapas Kumar Chaudhuri

Venkatramana Palla

Ya-Ping Zhang

Affiliations

Soon will be listed here.

Abstract

To resolve the phylogeny of the autochthonous mitochondrial DNA (mtDNA) haplogroups of India and determine the relationship between the Indian and western Eurasian mtDNA pools more precisely, a diverse subset of 75 macrohaplogroup N lineages was chosen for complete sequencing from a collection of >800 control-region sequences sampled across India. We identified five new autochthonous haplogroups (R7, R8, R30, R31, and N5) and fully characterized the autochthonous haplogroups (R5, R6, N1d, U2a, U2b, and U2c) that were previously described only by first hypervariable segment (HVS-I) sequencing and coding-region restriction-fragment-length polymorphism analysis. Our findings demonstrate that the Indian mtDNA pool, even when restricted to macrohaplogroup N, harbors at least as many deepest-branching lineages as the western Eurasian mtDNA pool. Moreover, the distribution of the earliest branches within haplogroups M, N, and R across Eurasia and Oceania provides additional evidence for a three-founder-mtDNA scenario and a single migration route out of Africa.

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