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Very Low Arylsulfatase A and Cerebroside Sulfatase Activities in Leukocytes of Healthy Members of Metachromatic Leukodystrophy Family

Overview
Journal Am J Hum Genet
Publisher Cell Press
Specialty Genetics
Date 1977 Mar 1
PMID 15452
Citations 27
Authors
G Dubois
K Harzer
N Baumann
Affiliations
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Abstract

Very low levels of arylsulfatase A (ASA) have been found in the leukocytes of healthy members of a metachromatic leukodystrophy (MLD) family. The cerebroside sulfate sulfatase (CSS) activities in the same individuals are about 10% of the control level. Arguments favoring a dominant mutation different from that of classical MLD are presented. This report reinforces the relationship between the two enzymatic activities.

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References
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Dubois G, Turpin J, Baumann N . Arylsulfatases isoenzymes in metachromatic leucodystrophy/detection of a new variant by electrophoresis improvement of quantitative assay. Biomedicine. 1975; 23(3):116-9. View
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