Characterization of Ursolic Acid As a Lipoxygenase and Cyclooxygenase Inhibitor Using Macrophages, Platelets and Differentiated HL60 Leukemic Cells

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1992 Mar 16

PMID 1544497

Citations 17

Authors

A Najid

A Simon

J Cook

C Delage

A J Chulia

M Rigaud

Affiliations

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Abstract

A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone-extract of heather flowers (Calluna vulgaris) which could help explain the anti-inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1 microM, blocks arachidonate metabolism.

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