» Articles » PMID: 1543863

Effect of Glycyrrhizin on Lysis of Hepatocyte Membranes Induced by Anti-liver Cell Membrane Antibody

Overview
Specialty Gastroenterology
Date 1992 Jan 1
PMID 1543863
Citations 17
Authors
Affiliations
Soon will be listed here.
Abstract

Studies were made on why glycyrrhizin injection decreases the plasma aspartate aminotransferase (AST) and alanine aminotransferase activities in patients with chronic hepatitis. For this, rat hepatocytes were isolated, and incubated with antibody raised against rat liver cell membranes, and the effect of glycyrrhizin on their release of transaminase was investigated. Isolated rat hepatocytes released AST on incubation with anti-liver cell antibody in the presence of complement. At this time, their endogenous phospholipase A2 activity was increased. Cultured hepatocytes also released the transaminase in the presence of venom phospholipase A2. Glycyrrhizin suppressed the release of transaminase in the presence of either anti-liver cell membrane antibody or phospholipase A2. These results suggest that antibody treatment raised the phospholipase A2 activity in liver cell membranes, resulting in release of transaminases, and that glycyrrhizin suppressed this increase in phospholipase A2 activity and so inhibited the release of transaminase.

Citing Articles

Can Antiviral Activity of Licorice Help Fight COVID-19 Infection?.

Diomede L, Beeg M, Gamba A, Fumagalli O, Gobbi M, Salmona M Biomolecules. 2021; 11(6).

PMID: 34201172 PMC: 8227143. DOI: 10.3390/biom11060855.


Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families.

Tewari D, Mocan A, Parvanov E, Sah A, Nabavi S, Huminiecki L Front Pharmacol. 2017; 8:519.

PMID: 28848436 PMC: 5554347. DOI: 10.3389/fphar.2017.00519.


A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation.

Chen J, Jiang H, Wu Y, Li Y, Gao Y Drug Des Devel Ther. 2015; 9:2265-75.

PMID: 25945038 PMC: 4408971. DOI: 10.2147/DDDT.S81722.


Treatment of Chronic Hepatitis due to Hepatitis C Virus (CH-C) in India: A Randomized Controlled Trial Comparing Daily Interferon-alfa-2b and Ribavirin with Daily Interferon-alfa-2b and Glycyrrhizin-A Multicenter Study.

Acharya S, Sreenivas V, Gupta S, Kumar S, Chawla Y, Tandon A J Clin Exp Hepatol. 2015; 2(1):10-8.

PMID: 25755401 PMC: 3940339. DOI: 10.1016/S0973-6883(12)60079-6.


Comparative study to evaluate the anti-viral efficacy of Glycyrrhiza glabra extract and ribavirin against the Newcastle disease virus.

Ovais Omer M, Almalki W, Shahid I, Khuram S, Altaf I, Imran S Pharmacognosy Res. 2014; 6(1):6-11.

PMID: 24497736 PMC: 3897011. DOI: 10.4103/0974-8490.122911.