Antigenicity and Immunogenicity of Collagen

Overview

Journal J Biomed Mater Res B Appl Biomater

Specialty Biomedical Engineering

Date 2004 Sep 24

PMID 15386396

Citations 195

Authors

A K Lynn

I V Yannas

W Bonfield

Affiliations

Soon will be listed here.

Abstract

Pertinent issues of collagen antigenicity and immunogenicity are concisely reviewed as they relate to the design and application of biomedical devices. A brief discussion of the fundamental concepts of collagen immunochemistry is presented, with a subsequent review of documented clinical responses to devices containing reconstituted soluble or solubilized collagen. The significance of atelocollagen, concerns regarding collagen-induced autoimmunity, and other relevant topics are also addressed in the context of current understanding of the human immune response to collagen.

Citing Articles

Biofunctionalization of Collagen Barrier Membranes with Bone-Conditioned Medium, as a Natural Source of Growth Factors, Enhances Osteoblastic Cell Behavior.

Ashoka Sreeja H, Couso-Queiruga E, Raabe C, Chappuis V, Asparuhova M Int J Mol Sci. 2025; 26(4).

PMID: 40004074 PMC: 11855076. DOI: 10.3390/ijms26041610.

Electrospun Collagen-Coated Nanofiber Membranes Functionalized with Silver Nanoparticles for Advanced Wound Healing Applications.

Iurilli M, Porrelli D, Turco G, Lagatolla C, Camurri Piloni A, Medagli B Membranes (Basel). 2025; 15(2).

PMID: 39997665 PMC: 11857158. DOI: 10.3390/membranes15020039.

Collagen Injections for Rotator Cuff Diseases: A Systematic Review.

Aicale R, Savarese E, Mottola R, Corrado B, Sirico F, Pellegrino R Clin Pract. 2025; 15(2).

PMID: 39996698 PMC: 11854470. DOI: 10.3390/clinpract15020028.

The Optimization of Culture Conditions for Injectable Recombinant Collagen Hydrogel Preparation Using Machine Learning.

Li M, Zhao L, Ren Y, Zuo L, Shen Z, Wu J Gels. 2025; 11(2).

PMID: 39996684 PMC: 11855032. DOI: 10.3390/gels11020141.

Integrating Physical and Biochemical Cues for Muscle Engineering: Scaffolds and Graft Durability.

Yousefi F, Foster L, Selim O, Zhao C Bioengineering (Basel). 2025; 11(12.

PMID: 39768063 PMC: 11673930. DOI: 10.3390/bioengineering11121245.