Why Calcium-stimulated Adenylyl Cyclases?

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2004 Sep 24

PMID 15381755

Citations 60

Authors

Gregory D Ferguson

Daniel R Storm

Affiliations

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Abstract

The Ca(2+)/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca(2+) increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.

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