The Los Alamos Hepatitis C Sequence Database

Overview

Journal Bioinformatics

Publisher Oxford University Press

Specialty Biology

Date 2004 Sep 21

PMID 15377502

Citations 189

Authors

Carla Kuiken

Karina Yusim

Laura Boykin

Russell Richardson

Affiliations

Soon will be listed here.

Abstract

Motivation: The hepatitis C virus (HCV) is a significant threat to public health worldwide. The virus is highly variable and evolves rapidly, making it an elusive target for the immune system and for vaccine and drug design. At present, some 30 000 HCV sequences have been published. A central website that provides annotated sequences and analysis tools will be helpful to HCV scientists worldwide.

Results: The HCV sequence database collects and annotates sequence data and provides them to the public via a website that contains a user-friendly search interface and a large number of sequence analysis tools, based on the model of the highly regarded Los Alamos HIV database. The HCV sequence database was officially launched in September 2003. Since then, its usage has steadily increased and is now at an average of approximately 280 visits per day from distinct IP addresses.

Availability: The HCV website can be accessed via http://hcv.lanl.gov and http://hcv-db.org.

Citing Articles

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Caudai C, Pierotti P, Rossetti B, Blanc P, Zazzi M Eur J Clin Microbiol Infect Dis. 2025; .

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analysis of the effect of HCV genotype-specific polymorphisms in Core, NS3, NS5A, and NS5B proteins on T-cell epitope processing and presentation.

Baig S, Berikkara A, Khalid R, Subhan S, Abbas T, Abidi S Front Microbiol. 2025; 15:1498069.

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Generation of Optimized Consensus Sequences for Hepatitis C virus (HCV) Envelope 2 Glycoprotein (E2) by a Modified Algorithm: Implication for a Pan-genomic HCV Vaccine.

Mohabati R, Rezaei R, Mohajel N, Ranjbar M, Samimi-Rad K, Azadmanesh K Avicenna J Med Biotechnol. 2024; 16(4):268-278.

PMID: 39606685 PMC: 11589427. DOI: 10.18502/ajmb.v16i4.16743.

Fine-tuning of hepatitis C virus immune evasion through hypervariable region 1 insertions.

Colpitts C, Baumert T Hepatology. 2024; .

PMID: 39437189 PMC: 7617289. DOI: 10.1097/HEP.0000000000001132.

Transmission network of Hepatitis C virus subtype 2a in Huazhou County, Shaanxi Province, China.

Zhang M, Ning S, Zhang L, Liu G, Chen S, Zhang Y BMC Infect Dis. 2024; 24(1):1048.

PMID: 39333968 PMC: 11428910. DOI: 10.1186/s12879-024-09929-2.