Regulation of Fc Receptor and Major Histocompatibility Complex Antigen Expression on Isolated Rat Microglia by Tumour Necrosis Factor, Interleukin-1 and Lipopolysaccharide: Effects on Interferon-gamma Induced Activation

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1992 Jan 1

PMID 1537593

Citations 14

Authors

A J Loughlin

M N Woodroofe

M L Cuzner

Affiliations

Soon will be listed here.

Abstract

Isolated rat brain microglia display enhanced expression of Fc receptors on treatment with interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and lipopolysaccharide (LPS), whereas major histocompatibility complex (MHC) antigen expression is enhanced only by IFN-gamma. Although TNF and LPS individually have no effect on MHC expression by microglia, they both antagonize IFN-gamma-induced expression. The enhanced expression of Fc receptors observed in the presence of IFN-gamma, TNF or LPS is significantly inhibited by the combination of IFN-gamma with either LPS or TNF. IL-1 alpha has little effect on IFN-gamma-induced MHC or Fc receptor expression by microglia. Peritoneal macrophages behave similarly to microglia, with the notable exception that IL-1 alpha enhances IFN-gamma-induced FcR expression. These observations suggest that the functional activity of microglia during inflammation or demyelination in the central nervous system can be influenced by the changing profile of cytokines present during lesion development.

Citing Articles

Fc receptors act as innate immune receptors during infection?.

Laassili C, Ben El Hend F, Benzidane R, Oumeslakht L, Aziz A, El Fatimy R Front Immunol. 2023; 14:1188497.

PMID: 37564652 PMC: 10410254. DOI: 10.3389/fimmu.2023.1188497.

The Functional Role of IgA in the IgM/IgA-Enriched Immunoglobulin Preparation Trimodulin.

Bohlander F, Weissmuller S, Riehl D, Gutscher M, Schuttrumpf J, Faust S Biomedicines. 2021; 9(12).

PMID: 34944644 PMC: 8698729. DOI: 10.3390/biomedicines9121828.

Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress.

Jurcau A Int J Mol Sci. 2021; 22(21).

PMID: 34769277 PMC: 8584731. DOI: 10.3390/ijms222111847.

Alzheimer's Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia.

Eshraghi M, Adlimoghaddam A, Mahmoodzadeh A, Sharifzad F, Yasavoli-Sharahi H, Lorzadeh S Int J Mol Sci. 2021; 22(7).

PMID: 33805142 PMC: 8036323. DOI: 10.3390/ijms22073330.

Therapeutic Potential of Intravenous Immunoglobulin in Acute Brain Injury.

Thom V, Arumugam T, Magnus T, Gelderblom M Front Immunol. 2017; 8:875.

PMID: 28824617 PMC: 5534474. DOI: 10.3389/fimmu.2017.00875.

References

Peudenier S, Hery C, Montagnier L, Tardieu M . Human microglial cells: characterization in cerebral tissue and in primary culture, and study of their susceptibility to HIV-1 infection. Ann Neurol. 1991; 29(2):152-61. DOI: 10.1002/ana.410290207. View

Vogel S, English K, Fertsch D, Fultz M . Differential modulation of macrophage membrane markers by interferon: analysis of Fc and C3b receptors, Mac-1 and Ia antigen expression. J Interferon Res. 1983; 3(2):153-60. DOI: 10.1089/jir.1983.3.153. View

Frendl G, Beller D . Regulation of macrophage activation by IL-3. I. IL-3 functions as a macrophage-activating factor with unique properties, inducing Ia and lymphocyte function-associated antigen-1 but not cytotoxicity. J Immunol. 1990; 144(9):3392-9. View

Woodroofe M, Hayes G, Cuzner M . Fc receptor density, MHC antigen expression and superoxide production are increased in interferon-gamma-treated microglia isolated from adult rat brain. Immunology. 1989; 68(3):421-6. PMC: 1385458. View

Arend W, Ammons J, Kotzin B . Lipopolysaccharide and interleukin 1 inhibit interferon-gamma-induced Fc receptor expression on human monocytes. J Immunol. 1987; 139(6):1873-9. View

Frei K, Siepl C, Groscurth P, Bodmer S, Schwerdel C, Fontana A . Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells. Eur J Immunol. 1987; 17(9):1271-8. DOI: 10.1002/eji.1830170909. View

Hayes G, Woodroofe M, Cuzner M . Characterisation of microglia isolated from adult human and rat brain. J Neuroimmunol. 1988; 19(3):177-89. DOI: 10.1016/0165-5728(88)90001-x. View

Warren M, Vogel S . Opposing effects of glucocorticoids on interferon-gamma-induced murine macrophage Fc receptor and Ia antigen expression. J Immunol. 1985; 134(4):2462-9. View

Prineas J, Kwon E, Cho E, Sharer L . Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques. Ann N Y Acad Sci. 1984; 436:11-32. DOI: 10.1111/j.1749-6632.1984.tb14773.x. View

10.

Woodroofe M, Sarna G, Wadhwa M, Hayes G, Loughlin A, Tinker A . Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J Neuroimmunol. 1991; 33(3):227-36. DOI: 10.1016/0165-5728(91)90110-s. View

11.

Watanabe Y, Jacob C . Regulation of MHC class II antigen expression. Opposing effects of tumor necrosis factor-alpha on IFN-gamma-induced HLA-DR and Ia expression depends on the maturation and differentiation stage of the cell. J Immunol. 1991; 146(3):899-905. View

12.

Zimmer T, Jones P . Combined effects of tumor necrosis factor-alpha, prostaglandin E2, and corticosterone on induced Ia expression on murine macrophages. J Immunol. 1990; 145(4):1167-75. View

13.

Becker S, Daniel E . Antagonistic and additive effects of IL-4 and interferon-gamma on human monocytes and macrophages: effects on Fc receptors, HLA-D antigens, and superoxide production. Cell Immunol. 1990; 129(2):351-62. DOI: 10.1016/0008-8749(90)90211-9. View

14.

Alvaro-Gracia J, Zvaifler N, Firestein G . Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production.... J Clin Invest. 1990; 86(6):1790-8. PMC: 329810. DOI: 10.1172/JCI114908. View

15.

Hofman F, Hinton D, Johnson K, Merrill J . Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med. 1989; 170(2):607-12. PMC: 2189402. DOI: 10.1084/jem.170.2.607. View

16.

Chang R, Lee S . Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line. J Immunol. 1986; 137(9):2853-6. View

17.

Suzumura A, Mezitis S, Gonatas N, Silberberg D . MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by gamma-interferon. J Neuroimmunol. 1987; 15(3):263-78. PMC: 7133952. DOI: 10.1016/0165-5728(87)90121-4. View

18.

Hayes G, Woodroofe M, Cuzner M . Microglia are the major cell type expressing MHC class II in human white matter. J Neurol Sci. 1987; 80(1):25-37. DOI: 10.1016/0022-510x(87)90218-8. View

19.

Giulian D, Baker T, Shih L, Lachman L . Interleukin 1 of the central nervous system is produced by ameboid microglia. J Exp Med. 1986; 164(2):594-604. PMC: 2188228. DOI: 10.1084/jem.164.2.594. View

20.

Jungi T . A rapid and sensitive method allowing photometric determination of erythrophagocytosis by mononuclear phagocytes. J Immunol Methods. 1985; 82(1):141-53. DOI: 10.1016/0022-1759(85)90233-9. View