No Relation Between Angiotensin-converting Enzyme Gene Polymorphism and Smoking Dependence

Overview

Journal Scand J Clin Lab Invest

Publisher Informa Healthcare

Specialty Science

Date 2004 Sep 17

PMID 15370463

Citations 5

Authors

J A Hubacek

V Adamkova

Z Skodova

V Lanska

R Poledne

Affiliations

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Abstract

Background: Smoking as a major risk factor for development of cancer and cardiovascular disease is thought to be partially genetically determined. The aim of this study was to investigate whether there is an association between insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme (ACE) and smoking status and the number of cigarettes smoked per week.

Methods: Using polymerase chain reaction, I/D polymorphism was evaluated in the ACE gene in 1204 male and 1375 female representative Caucasians. Information about smoking status and number of cigarettes smoked per week was collected via a questionnaire.

Results: Frequencies of the alleles and genotypes of ACE I/D polymorphism did not differ between smokers, past smokers and individuals who had never smoked. No association was found between ACE I/D polymorphism and the number of cigarettes smoked per week, either in males or in females.

Conclusion: I/D polymorphism in the ACE gene does not play any role in genetic determination of predisposition to smoking.

Citing Articles

Association between the ACE-I/D polymorphism and nicotine dependence amongst patients with lung cancer.

Nadalin S, Flego V, Devic Pavlic S, Volaric D, Radojcic Badovinac A, Kapovic M Biomed Rep. 2020; 13(6):58.

PMID: 33123372 PMC: 7583696. DOI: 10.3892/br.2020.1365.

The lack of association between angiotensin-converting enzyme gene insertion/deletion polymorphism and nicotine dependence in multiple sclerosis.

Nadalin S, Buretic-Tomljanovic A, Lavtar P, Starcevic cizmarevic N, Hodzic A, Sepcic J Brain Behav. 2017; 7(1):e00600.

PMID: 28127518 PMC: 5256183. DOI: 10.1002/brb3.600.

Smoking has no impact on survival and it is not associated with ACE gene I/D polymorphism in hemodialysis patients.

Kiss I, Kiss Z, Kerkovits L, Paksy A, Ambrus C J Renin Angiotensin Aldosterone Syst. 2017; 18(1):1470320316667831.

PMID: 28058974 PMC: 5843857. DOI: 10.1177/1470320316667831.

The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients.

Nadalin S, Ristic S, Rebic J, Sendula Jengic V, Kapovic M, Buretic-Tomljanovic A J Neural Transm (Vienna). 2016; 124(4):511-518.

PMID: 28028641 DOI: 10.1007/s00702-016-1670-y.

Association of Angiotensin converting enzyme gene insertion / deletion polymorphism with risk of ischemic heart disease in a population of smokers in southern India.

Metta S, Uppala S, Basalingappa D, Badeti S, Mitta G, Mohanty S J Clin Diagn Res. 2015; 9(4):GC01-4.

PMID: 26023569 PMC: 4437083. DOI: 10.7860/JCDR/2015/12634.5852.