Smooth Muscle Fraction of the Round Ligament in Women with Pelvic Organ Prolapse: a Computer-based Morphometric Analysis

Overview

Journal Int Urogynecol J Pelvic Floor Dysfunct

Specialties Gynecology & Obstetrics
Urology

Date 2004 Sep 15

PMID 15365597

Citations 13

Authors

Ozlem Ozdegirmenci

Yildirim Karslioglu

Suat Dede

Sinan Karadeniz

Ali Haberal

Omer Gunhan

Bulent Celasun

Affiliations

Soon will be listed here.

Abstract

Our objective was to compare the collagen and muscle content of the round ligament of uteri in women with pelvic organ prolapse. We evaluated the tissue samples obtained from the round ligaments of 22 patients with uterine prolapse who underwent vaginal hysterectomy (group A, study) and from 26 patients with no pelvic relaxation in whom total abdominal hysterectomy was performed for benign reasons (group B, controls). Morphometric analysis was performed on histologic cross-sections of the round ligament. Sections from each sample were stained with hematoxylin and eosin and Masson's trichrome methods. A computer system was used for morphometric measurements. We used independent samples t-test or Mann-Whitney U test to investigate the difference between the two groups. It was found that the smooth muscle fraction of the round ligament in women with uterine prolapse was significantly decreased compared with that of healthy control subjects and concluded that decreased smooth muscle content may be an important pathogenetic factor in uterine prolapse.

Citing Articles

Evaluation of Neuromuscular Morphometry of the Vaginal Wall Using Protein Gene Product 9.5 (Pgp 9.5) and Smooth Muscle α-Actin (Sma) in Patients with Posterior Vaginal Wall Prolapse.

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Comparison of outcomes between preservation or division of the uterine round ligament in laparoscopic groin hernia repair in females: a meta-analysis and trial sequential analysis.

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Effect of modified laparoscopic hysterectomy on pelvic floor function: A retrospective observational study.

Lee C, Tseng C, Chang C, Lee M, Ou Y, Yang S Medicine (Baltimore). 2019; 98(8):e14616.

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Oxidative status of cardinal ligament in pelvic organ prolapse.

Fang G, Hong L, Liu C, Yang Q, Zhang Q, Li Y Exp Ther Med. 2018; 16(4):3293-3302.

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Proteomic Analysis of the Uterosacral Ligament in Postmenopausal Women with and without Pelvic Organ Prolapse.

Sun Z, Zhu L, Lang J, Wang Z, Liang S Chin Med J (Engl). 2015; 128(23):3191-6.

PMID: 26612295 PMC: 4794882. DOI: 10.4103/0366-6999.170262.

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