E2F Target Genes: Unraveling the Biology

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2004 Sep 15

PMID 15362224

Citations 295

Authors

Adrian P Bracken

Marco Ciro

Andrea Cocito

Kristian Helin

Affiliations

Soon will be listed here.

Abstract

The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.

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