The Role of Cdx Genes in the Mammalian Gut

Overview

Journal Gut

Specialty Gastroenterology

Date 2004 Sep 14

PMID 15361482

Citations 40

Authors

F Beck

Affiliations

Soon will be listed here.

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References

Capecchi M . Altering the genome by homologous recombination. Science. 1989; 244(4910):1288-92. DOI: 10.1126/science.2660260. View

James R, Kazenwadel J . Homeobox gene expression in the intestinal epithelium of adult mice. J Biol Chem. 1991; 266(5):3246-51. View

Meyer B, Gruss P . Mouse Cdx-1 expression during gastrulation. Development. 1993; 117(1):191-203. DOI: 10.1242/dev.117.1.191. View

Gamer L, Wright C . Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern. Mech Dev. 1993; 43(1):71-81. DOI: 10.1016/0925-4773(93)90024-r. View

Burke A, Nelson C, Morgan B, Tabin C . Hox genes and the evolution of vertebrate axial morphology. Development. 1995; 121(2):333-46. DOI: 10.1242/dev.121.2.333. View

Subramanian V, Meyer B, Gruss P . Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell. 1995; 83(4):641-53. DOI: 10.1016/0092-8674(95)90104-3. View

Silberg D, Sullivan J, Kang E, Swain G, Moffett J, Sund N . Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology. 2002; 122(3):689-96. DOI: 10.1053/gast.2002.31902. View

Mutoh H, Hakamata Y, Sato K, Eda A, Yanaka I, Honda S . Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun. 2002; 294(2):470-9. DOI: 10.1016/S0006-291X(02)00480-1. View

Kim S, Domon-Dell C, Wang Q, Chung D, Di Cristofano A, Pandolfi P . PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Gastroenterology. 2002; 123(4):1163-78. DOI: 10.1053/gast.2002.36043. View

10.

Beck F, Chawengsaksophak K, Luckett J, Giblett S, Tucci J, Brown J . A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice. Dev Biol. 2003; 255(2):399-406. DOI: 10.1016/s0012-1606(02)00096-9. View

11.

Bonhomme C, Duluc I, Martin E, Chawengsaksophak K, Chenard M, Kedinger M . The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut. 2003; 52(10):1465-71. PMC: 1773830. DOI: 10.1136/gut.52.10.1465. View

12.

Aoki K, Tamai Y, Horiike S, Oshima M, Taketo M . Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet. 2003; 35(4):323-30. DOI: 10.1038/ng1265. View

13.

Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F . Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A. 2004; 101(20):7641-5. PMC: 419659. DOI: 10.1073/pnas.0401654101. View

14.

Mutoh H, Sakurai S, Satoh K, Osawa H, Hakamata Y, Takeuchi T . Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice. Gut. 2004; 53(10):1416-23. PMC: 1774241. DOI: 10.1136/gut.2003.032482. View

15.

Willems G, Lehy T . Radioautographic and quantitative studies on parietal and peptic cell kinetics in the mouse. A selective effect of gastrin on parietal cell proliferation. Gastroenterology. 1975; 69(2):416-26. View

16.

Beck F, Erler T, Russell A, James R . Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev Dyn. 1995; 204(3):219-27. DOI: 10.1002/aja.1002040302. View

17.

Offield M, Jetton T, Labosky P, Ray M, Stein R, Magnuson M . PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996; 122(3):983-95. DOI: 10.1242/dev.122.3.983. View

18.

Chawengsaksophak K, James R, Hammond V, Kontgen F, Beck F . Homeosis and intestinal tumours in Cdx2 mutant mice. Nature. 1997; 386(6620):84-7. DOI: 10.1038/386084a0. View

19.

Troelsen J, Mitchelmore C, Spodsberg N, Jensen A, Noren O, Sjostrom H . Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2. Biochem J. 1997; 322 ( Pt 3):833-8. PMC: 1218263. DOI: 10.1042/bj3220833. View

20.

Brooke N, Garcia-Fernandez J, Holland P . The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster. Nature. 1998; 392(6679):920-2. DOI: 10.1038/31933. View