The Secretion Signal of YopN, a Regulatory Protein of the Yersinia Enterocolitica Type III Secretion Pathway

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2004 Sep 3

PMID 15342604

Citations 8

Authors

John W Goss

Joseph A Sorg

Kumaran S Ramamurthi

Hung Ton-That

Olaf Schneewind

Affiliations

Soon will be listed here.

Abstract

The type III secretion signal of Yersinia enterocolitica YopN was mapped using a gene fusion approach. yopN codons 1 to 12 were identified as critical for signal function. Several synonymous mutations that abolish secretion of hybrid proteins without altering the codon specificity of yopN mRNA were identified.

Citing Articles

Genetically engineered frameshifted YopN-TyeA chimeras influence type III secretion system function in Yersinia pseudotuberculosis.

Amer A, Costa T, Farag S, Avican U, Forsberg A, Francis M PLoS One. 2013; 8(10):e77767.

PMID: 24098594 PMC: 3789692. DOI: 10.1371/journal.pone.0077767.

The SycN/YscB chaperone-binding domain of YopN is required for the calcium-dependent regulation of Yop secretion by Yersinia pestis.

Joseph S, Plano G Front Cell Infect Microbiol. 2013; 3:1.

PMID: 23355975 PMC: 3553376. DOI: 10.3389/fcimb.2013.00001.

Functional and computational analysis of amino acid patterns predictive of type III secretion system substrates in Pseudomonas syringae.

Schechter L, Valenta J, Schneider D, Collmer A, Sakk E PLoS One. 2012; 7(4):e36038.

PMID: 22558318 PMC: 3338616. DOI: 10.1371/journal.pone.0036038.

Timing is everything: the regulation of type III secretion.

Deane J, Abrusci P, Johnson S, Lea S Cell Mol Life Sci. 2010; 67(7):1065-75.

PMID: 20043184 PMC: 2835726. DOI: 10.1007/s00018-009-0230-0.

Impassable YscP substrates and their impact on the Yersinia enterocolitica type III secretion pathway.

Riordan K, Sorg J, Berube B, Schneewind O J Bacteriol. 2008; 190(18):6204-16.

PMID: 18641141 PMC: 2546781. DOI: 10.1128/JB.00467-08.

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