Immunomodulating Activity of Rifampicin

Overview

Journal J Chemother

Specialties Infectious Diseases
Oncology

Date 2004 Aug 31

PMID 15332711

Citations 23

Authors

H M Ziglam

I Daniels

R G Finch

Affiliations

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Abstract

It has been shown that some antibiotics can modify cytokine production. We have examined the effect of rifampicin on secretion of interleukin-1beta (IL-1beta), IL-6, IL-10, and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide (LPS)-stimulated or heat killed staphylococci (Pansorbin) stimulated monocytes. Secretion of IL-1beta and TNF-a were significantly inhibited (P<0.002) whereas secretion of IL-6 and IL-10 were significantly increased (P<0.003) by rifampicin treated mononuclear cells. Rifampicin had immunomodulatory effects through its capacity to alter the secretion of tested cytokines by human monocytes.

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