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[Meta-analysis of Surgery Trials in Refractory Epilepsy]

Overview
Specialty Neurology
Date 2004 Aug 28
PMID 15331971
Citations 2
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Abstract

Objective: To examine the evidence for efficacy of surgery in the treatment of intractable epilepsy.

Method: Meta-analysis of randomized clinical trials.

Results: One randomized clinical trial (n=80) and 3 observational studies are available.

Interpretation: Compared to medical treatment, the surgery increases the proportion of patients who were free of seizure impairing awareness at 1 year (relative risk: 7.67, IC 95% 2.5 à 23.51)

Conclusion: The available evidence about the clinical efficacy of surgery for patient with intractable epilepsies is limited to an unique open randomized clinical trial, that enrolled patient in a single centre, without concealment of the randomization and with a partially subjective primary endpoint. However, this trial shows a substantial effect corresponding to a 8 fold increase in the number of patient without seizure at 1 year. The informational situation will be better when the results of a currently ongoing trial will be available.

Citing Articles

Epilepsy (partial).

Maguire M, Marson A, Ramaratnam S BMJ Clin Evid. 2011; 2011.

PMID: 21549021 PMC: 3217777.


Comparative analysis of MR imaging, ictal SPECT and EEG in temporal lobe epilepsy: a prospective IAEA multi-center study.

Zaknun J, Bal C, Maes A, Tepmongkol S, Vazquez S, Dupont P Eur J Nucl Med Mol Imaging. 2007; 35(1):107-15.

PMID: 17899076 DOI: 10.1007/s00259-007-0526-y.