Dorsal-ventral Patterning in Drosophila: DNA Binding of Snail Protein to the Single-minded Gene

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1992 Apr 15

PMID 1533042

Citations 28

Authors

Y Kasai

J R Nambu

P M Lieberman

S T Crews

Affiliations

Soon will be listed here.

Abstract

The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These results provide evidence for the direct control of sim transcription by snail.

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