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Nicorandil: a Review of Its Use in the Management of Stable Angina Pectoris, Including High-risk Patients

Overview
Journal Drugs
Specialty Pharmacology
Date 2004 Aug 27
PMID 15329045
Citations 12
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Abstract

Nicorandil (Adancor, Angicor, Dancor, Nikoril [Europe], Ikorel [Europe and Oceania], Sigmart [Japan, Korea and Taiwan]) is an adenosine triphosphate (ATP)-sensitive potassium (KATP) channel agonist with nitrate-like properties used in the management of stable angina pectoris. With well established monotherapeutic antianginal activity and a beneficial effect (when added to optimal antianginal therapy) on clinical outcomes in high-risk patients with stable angina, twice-daily oral nicorandil is a useful alternative or addition to other antianginal therapy.

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References
1.
DORING G . Antianginal and anti-ischemic efficacy of nicorandil in comparison with isosorbide-5-mononitrate and isosorbide dinitrate: results from two multicenter, double-blind, randomized studies with stable coronary heart disease patients. J Cardiovasc Pharmacol. 1992; 20 Suppl 3:S74-81. View

2.
. Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial. Lancet. 2002; 359(9314):1269-75. DOI: 10.1016/S0140-6736(02)08265-X. View

3.
Rajaratnam R, Brieger D, Hawkins R, Freedman S . Attenuation of anti-ischemic efficacy during chronic therapy with nicorandil in patients with stable angina pectoris. Am J Cardiol. 1999; 83(7):1120-4, A9. DOI: 10.1016/s0002-9149(99)00025-9. View

4.
Iwai T, Tanonaka K, Motegi K, Inoue R, Kasahara S, Takeo S . Nicorandil preserves mitochondrial function during ischemia in perfused rat heart. Eur J Pharmacol. 2002; 446(1-3):119-27. DOI: 10.1016/s0014-2999(02)01645-x. View

5.
Minamino T, Jiyoong K, Asakura M, Shintani Y, Asanuma H, Kitakaze M . Rationale and design of a large-scale trial using nicorandil as an adjunct to percutaneous coronary intervention for ST-segment elevation acute myocardial infarction: Japan-Working groups of acute myocardial infarction for the reduction of Necrotic.... Circ J. 2004; 68(2):101-6. DOI: 10.1253/circj.68.101. View