Bone Health. New Role for Vitamin K?

Overview

Journal Can Fam Physician

Specialties General Medicine
Public Health

Date 2004 Aug 20

PMID 15317231

Citations 5

Authors

Milly Ryan-Harshman

Walid Aldoori

Affiliations

Soon will be listed here.

Abstract

Objective: To assess growing evidence that vitamin K (phylloquinone) plays an important role in bone health and, subsequently, in prevention of osteoporotic fractures.

Quality Of Evidence: We searched MEDLINE from January 1972 to December 2002 using the key words vitamin K and bone health. We reviewed 30 articles that seemed relevant or had a human focus. All evidence can be categorized as level II.

Main Message: Evidence suggests that dietary phylloquinone intake of <100 microg daily might not be optimal for bone health. Low intake of vitamin K could contribute to osteoporosis and subsequent fracture due to the undercarboxylation of osteocalcin.

Conclusion: Family physicians need to be aware of the importance of encouraging adequate vitamin K intake, particularly among institutionalized elderly people, to prevent increased bone resorption. Further study is needed to determine the exact role of vitamin K in bone metabolism, and methods of assessing vitamin K requirements need to be standardized.

Citing Articles

Vitamin K-Dependent Matrix Gla Protein as Multifaceted Protector of Vascular and Tissue Integrity.

Wei F, Trenson S, Verhamme P, Vermeer C, Staessen J Hypertension. 2019; 73(6):1160-1169.

PMID: 31006332 PMC: 6510326. DOI: 10.1161/HYPERTENSIONAHA.119.12412.

Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study.

Ozgen M, Cosan D, Doganer F, Soyocak A, Armagan O, Kuzgun S Clinics (Sao Paulo). 2019; 74:e739.

PMID: 30892416 PMC: 6399659. DOI: 10.6061/clinics/2019/e739.

The health benefits of vitamin K.

DiNicolantonio J, Bhutani J, OKeefe J Open Heart. 2015; 2(1):e000300.

PMID: 26468402 PMC: 4600246. DOI: 10.1136/openhrt-2015-000300.

Combination of Micronutrients for Bone (COMB) Study: bone density after micronutrient intervention.

Genuis S, Bouchard T J Environ Public Health. 2012; 2012:354151.

PMID: 22291722 PMC: 3265100. DOI: 10.1155/2012/354151.

Health benefits of selected vitamins.

Ryan-Harshman M, Aldoori W Can Fam Physician. 2005; 51:965-8.

PMID: 16060174 PMC: 1479519.

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