Retinosomes: New Insights into Intracellular Managing of Hydrophobic Substances in Lipid Bodies

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2004 Aug 18

PMID 15314061

Citations 61

Authors

Yoshikazu Imanishi

Volker Gerke

Krzysztof Palczewski

Affiliations

Soon will be listed here.

Abstract

Lipid bodies form autonomous intracellular structures in many model cells and in some cells of specific tissue origin. They contain hydrophobic substances, a set of structural proteins such as perilipin or adipose differentiation-related protein, enzymes implicated in lipid metabolism, and proteins that participate in signaling and membrane trafficking. Retinosomes, particles reminiscent of lipid bodies, have been identified in retinal pigment epithelium as distinct structures compartmentalizing a metabolic intermediate involved in regeneration of the visual chromophore. These observations suggest that lipid bodies, including retinosomes, carry out specific functions that go beyond those of mere lipid storage organelles.

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