Impaired Rectoanal Inhibitory Response in Scleroderma (systemic Sclerosis): an Association with Fecal Incontinence

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2004 Aug 18

PMID 15309898

Citations 22

Authors

Gregory J Heyt

Mina K Oh

Nazanin Alemzadeh

Susie Rivera

Sergio A Jimenez

Satish Rattan

Sidney Cohen

Anthony J Dimarino Jr

Affiliations

Soon will be listed here.

Abstract

Gastrointestinal abnormalities in systemic sclerosis (SSc) involve both myogenic and neural mechanisms. The aims of this study were to evaluate the rectoanal inhibitory response (RAIR) in SSc patients and to correlate RAIR with duration and subtype of disease, antibody status, and lower gastrointestinal symptoms. Thirty-five patients with SSc completed a questionnaire and underwent anorectal manometry (ARM). Forty-five patients without SSc served as controls. In the 35 SSc patients, 62.3% reported diarrhea, 57.1% reported constipation, and 37.1% reported fecal incontinence. Twenty-five of the 35 scleroderma patients (71.4%) demonstrated an impaired or absent RAIR, compared with none of the 45 controls (P < 0.001). Eleven of 13 incontinent SSc patients (84%) had an impaired RAIR. No correlation was found between RAIR and duration or subtype of SSc, antibody status, or presence of diarrhea or constipation. Impaired RAIR was closely correlated with fecal incontinence, suggesting a possible neural mechanism for maintenance of continence.

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