Block of T -Type Ca(2+) Channels Is an Important Action of Succinimide Antiabsence Drugs

Overview

Journal Epilepsy Curr

Publisher Sage Publications

Date 2004 Aug 17

PMID 15309165

Citations 14

Authors

John R Huguenard

Affiliations

Soon will be listed here.

Abstract

The role of calcium channel blockade in the antiepileptic action of ethosuximide is controversial, especially regarding the potency and efficacy of block. However, recent evidence obtained from transgenic animals and heterologous expression systems supports a major role of T-type calcium channels in both the generation of absence seizures and the action of ethosuximide in human absence epilepsy.

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References

Kim D, Song I, Keum S, Lee T, Jeong M, Kim S . Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels. Neuron. 2001; 31(1):35-45. DOI: 10.1016/s0896-6273(01)00343-9. View

Gross R, Covey D, Ferrendelli J . Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones. J Pharmacol Exp Ther. 1997; 280(2):686-94. View

Avery R, Johnston D . Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons. J Neurosci. 1996; 16(18):5567-82. PMC: 6578965. View

Todorovic S, Lingle C . Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J Neurophysiol. 1998; 79(1):240-52. DOI: 10.1152/jn.1998.79.1.240. View

Kao C, Coulter D . Physiology and pharmacology of corticothalamic stimulation-evoked responses in rat somatosensory thalamic neurons in vitro. J Neurophysiol. 1997; 77(5):2661-76. DOI: 10.1152/jn.1997.77.5.2661. View

Talley E, Solorzano G, Depaulis A, Perez-Reyes E, Bayliss D . Low-voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat. Brain Res Mol Brain Res. 2000; 75(1):159-65. DOI: 10.1016/s0169-328x(99)00307-1. View

Coulter D, Huguenard J, Prince D . Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. Br J Pharmacol. 1990; 100(4):800-6. PMC: 1917607. DOI: 10.1111/j.1476-5381.1990.tb14095.x. View

Leresche N, Parri H, Erdemli G, Guyon A, Turner J, Williams S . On the action of the anti-absence drug ethosuximide in the rat and cat thalamus. J Neurosci. 1998; 18(13):4842-53. PMC: 6792570. View

Warren R, Agmon A, Jones E . Oscillatory synaptic interactions between ventroposterior and reticular neurons in mouse thalamus in vitro. J Neurophysiol. 1994; 72(4):1993-2003. DOI: 10.1152/jn.1994.72.4.1993. View

10.

Steriade M, McCormick D, Sejnowski T . Thalamocortical oscillations in the sleeping and aroused brain. Science. 1993; 262(5134):679-85. DOI: 10.1126/science.8235588. View

11.

Coulter D, Huguenard J, Prince D . Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol. 1989; 25(6):582-93. DOI: 10.1002/ana.410250610. View

12.

Gomora J, Daud A, Weiergraber M, Perez-Reyes E . Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol Pharmacol. 2001; 60(5):1121-32. View

13.

Von Krosigk M, Bal T, McCormick D . Cellular mechanisms of a synchronized oscillation in the thalamus. Science. 1993; 261(5119):361-4. DOI: 10.1126/science.8392750. View

14.

Tsakiridou E, Bertollini L, de Curtis M, Avanzini G, Pape H . Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy. J Neurosci. 1995; 15(4):3110-7. PMC: 6577780. View

15.

Coulter D, Huguenard J, Prince D . Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current. J Physiol. 1989; 414:587-604. PMC: 1189159. DOI: 10.1113/jphysiol.1989.sp017705. View

16.

Lacinova L, Klugbauer N, Hofmann F . Regulation of the calcium channel alpha(1G) subunit by divalent cations and organic blockers. Neuropharmacology. 2000; 39(7):1254-66. DOI: 10.1016/s0028-3908(99)00202-6. View

17.

Huguenard J, Prince D . Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects. J Neurosci. 1994; 14(9):5485-502. PMC: 6577071. View

18.

Herrington J, Lingle C . Kinetic and pharmacological properties of low voltage-activated Ca2+ current in rat clonal (GH3) pituitary cells. J Neurophysiol. 1992; 68(1):213-32. DOI: 10.1152/jn.1992.68.1.213. View

19.

SAYER R, Brown A, Schwindt P, CRILL W . Calcium currents in acutely isolated human neocortical neurons. J Neurophysiol. 1993; 69(5):1596-606. DOI: 10.1152/jn.1993.69.5.1596. View

20.

Talley E, Cribbs L, Lee J, Daud A, Perez-Reyes E, Bayliss D . Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J Neurosci. 1999; 19(6):1895-911. PMC: 6782581. View