Regulatory Role of E-NTPase/E-NTPDase in Ca2+/Mg2+ Transport Via Gated Channel

Overview

Journal Theor Biol Med Model

Publisher Biomed Central

Date 2004 Aug 17

PMID 15307889

Citations 2

Authors

Hans M Schreiber

Subburaj Kannan

Affiliations

Soon will be listed here.

Abstract

Background: E-NTPase/E-NTPDase is activated by millimolar concentrations of Ca2+ or Mg2+ with a pH optimum of 7.5 for the hydrolysis of extracellular NTP and NDP. It has been generally accepted that E-NTPase/E-NTPDase plays regulatory role in purinergic signalling, but other functions may yet be discovered.

Results: In this article it is proposed on the basis of published data that E-NTPase/E-NTPDase could play a role in the influx and efflux of Ca2+and Mg2+ in vivo.

Conclusions: Attenuation of extracellular Ca2+ influx by rat cardiac sarcoplasmic anti-E-NTPase antibodies and oligomerization studies on mammalian CD39 conclusively point towards the existence of a new channel in the membrane. Further studies on these properties of the E-NTPase/E-NTPDase may provide detailed mechanisms and identify the potential patho-physiological significance.

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