The Relationship Between T-lymphocyte Subset Infiltration and Survival in Patients with Prostate Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 2004 Jul 22

PMID 15266325

Citations 67

Authors

P A McArdle

K Canna

D C McMillan

A-M McNicol

R Campbell

M A Underwood

Affiliations

Soon will be listed here.

Abstract

The relationship between tumour stage, T-lymphocyte subset infiltration and survival was examined in patients with prostate cancer (n=80). On multivariate analysis PSA (HR 2.47, 95% CI 1.27-4.83, P=0.008) and CD4+ T-lymphocyte count (HR 2.29, 95% CI 1.25-4.22, P=0.008) had independent significance. Increased CD4+ T-lymphocyte infiltration within the tumour was stage independent and associated with poor outcome in patients with prostate cancer.

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References

Vesalainen S, Lipponen P, Talja M, Syrjanen K . Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma. Eur J Cancer. 1994; 30A(12):1797-803. DOI: 10.1016/0959-8049(94)e0159-2. View

Chodak G, Thisted R, Gerber G, Johansson J, Adolfsson J, Jones G . Results of conservative management of clinically localized prostate cancer. N Engl J Med. 1994; 330(4):242-8. DOI: 10.1056/NEJM199401273300403. View

Ropponen K, Eskelinen M, Lipponen P, Alhava E, Kosma V . Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol. 1997; 182(3):318-24. DOI: 10.1002/(SICI)1096-9896(199707)182:3<318::AID-PATH862>3.0.CO;2-6. View

Nielsen H, Hansen U, Christensen I, Reimert C, Brunner N, Moesgaard F . Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue. J Pathol. 2000; 189(4):487-95. DOI: 10.1002/(SICI)1096-9896(199912)189:4<487::AID-PATH484>3.0.CO;2-I. View

Bromwich E, McArdle P, Canna K, McMillan D, McNicol A, Brown M . The relationship between T-lymphocyte infiltration, stage, tumour grade and survival in patients undergoing curative surgery for renal cell cancer. Br J Cancer. 2003; 89(10):1906-8. PMC: 2394435. DOI: 10.1038/sj.bjc.6601400. View

Coussens L, Werb Z . Inflammation and cancer. Nature. 2002; 420(6917):860-7. PMC: 2803035. DOI: 10.1038/nature01322. View

Ali A, McMillan D, Matalka I, McNicol A, McArdle C . Tumour T-lymphocyte subset infiltration and tumour recurrence following curative resection for colorectal cancer. Eur J Surg Oncol. 2004; 30(3):292-5. DOI: 10.1016/j.ejso.2003.11.018. View

Nakano O, Sato M, Naito Y, Suzuki K, Orikasa S, Aizawa M . Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res. 2001; 61(13):5132-6. View

Jass J, Love S, Northover J . A new prognostic classification of rectal cancer. Lancet. 1987; 1(8545):1303-6. DOI: 10.1016/s0140-6736(87)90552-6. View

10.

Wilkinson B, Hamdy F . State-of-the-art staging in prostate cancer. BJU Int. 2001; 87(5):423-30. DOI: 10.1046/j.1464-410x.2001.02146.x. View

11.

Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H . CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res. 1998; 58(16):3491-4. View

12.

Naoe M, Marumoto Y, Ishizaki R, Ogawa Y, Nakagami Y, Yoshida H . Correlation between major histocompatibility complex class I molecules and CD8+ T lymphocytes in prostate, and quantification of CD8 and interferon-gamma mRNA in prostate tissue specimens. BJU Int. 2002; 90(7):748-53. DOI: 10.1046/j.1464-410x.2002.02993.x. View

13.

Irani J, Goujon J, Ragni E, Peyrat L, Hubert J, Saint F . High-grade inflammation in prostate cancer as a prognostic factor for biochemical recurrence after radical prostatectomy. Pathologist Multi Center Study Group. Urology. 1999; 54(3):467-72. DOI: 10.1016/s0090-4295(99)00152-1. View