Inhibition of IL-6 for the Treatment of Inflammatory Diseases

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2004 Jul 15

PMID 15251133

Citations 54

Authors

Norihiro Nishimoto

Tadamitsu Kishimoto

Affiliations

Soon will be listed here.

Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine with various biological activities. Deregulated overproduction of IL-6 has been found to play pathological roles in chronic inflammatory diseases such as rheumatoid arthritis, Castleman's disease, juvenile idiopathic arthritis and Crohn's disease. Humanized anti-IL-6 receptor antibody has been developed as a therapeutic agent for these diseases, and therapeutic benefits have been revealed in clinical studies.

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