A Role for Streptococcus Pneumoniae in Virus-associated Pneumonia

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2004 Jul 13

PMID 15247911

Citations 216

Authors

Shabir A Madhi

Keith P Klugman

Affiliations

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Abstract

Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15-43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia.

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