Interleukin-6 and Insulin Sensitivity: Friend or Foe?

Overview

Journal Diabetologia

Specialty Endocrinology

Date 2004 Jul 9

PMID 15241593

Citations 46

Authors

A L Carey

M A Febbraio

Affiliations

Soon will be listed here.

Citing Articles

Targeting inerleukin-6 for renoprotection.

Gubernatorova E, Samsonov M, Drutskaya M, Lebedeva S, Bukhanova D, Materenchuk M Front Immunol. 2024; 15:1502299.

PMID: 39723211 PMC: 11668664. DOI: 10.3389/fimmu.2024.1502299.

Immunology of Physical Exercise: Is an Appropriate Animal Model for Human Athletes?.

Witkowska-Pilaszewicz O, Malin K, Dabrowska I, Grzedzicka J, Ostaszewski P, Carter C Int J Mol Sci. 2024; 25(10).

PMID: 38791248 PMC: 11121269. DOI: 10.3390/ijms25105210.

Association of pro-inflammatory cytokines, adipokines and hepatokine with incident diabetes in India: a nested case-control study within CARRS cohort.

Gupta R, Shivashankar R, Kondal D, Gokulakrishnan K, Patel S, Ali M Acta Diabetol. 2024; 61(5):577-586.

PMID: 38315202 PMC: 11812286. DOI: 10.1007/s00592-023-02229-2.

Impact of Moderate Physical Activity on Inflammatory Markers and Telomere Length in Sedentary and Moderately Active Individuals with Varied Insulin Sensitivity.

Almuraikhy S, Sellami M, Al-Amri H, Domling A, Althani A, Elrayess M J Inflamm Res. 2023; 16:5427-5438.

PMID: 38026244 PMC: 10674740. DOI: 10.2147/JIR.S429899.

The effect of sodium-glucose co-transporter-2 (SGLT2) inhibitors on blood interleukin-6 concentration: a systematic review and meta-analysis of randomized controlled trials.

Gohari S, Ismail-Beigi F, Mahjani M, Ghobadi S, Jafari A, Ahangar H BMC Endocr Disord. 2023; 23(1):257.

PMID: 37996879 PMC: 10668472. DOI: 10.1186/s12902-023-01512-1.

References

Kanemaki T, Kitade H, Kaibori M, Sakitani K, Hiramatsu Y, Kamiyama Y . Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes. Hepatology. 1998; 27(5):1296-303. DOI: 10.1002/hep.510270515. View

Rumbaugh K, Colmer J, Griswold J, Hamood A . The effects of infection of thermal injury by Pseudomonas aeruginosa PAO1 on the murine cytokine response. Cytokine. 2002; 16(4):160-8. DOI: 10.1006/cyto.2001.0960. View

Hotamisligil G, Shargill N, Spiegelman B . Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993; 259(5091):87-91. DOI: 10.1126/science.7678183. View

Fernandez-Real J, Broch M, Vendrell J, Gutierrez C, Casamitjana R, Pugeat M . Interleukin-6 gene polymorphism and insulin sensitivity. Diabetes. 2000; 49(3):517-20. DOI: 10.2337/diabetes.49.3.517. View

Watchorn T, Waddell I, Dowidar N, Ross J . Proteolysis-inducing factor regulates hepatic gene expression via the transcription factors NF-(kappa)B and STAT3. FASEB J. 2001; 15(3):562-4. DOI: 10.1096/fj.00-0534fje. View

Pickup J, Chusney G, Thomas S, Burt D . Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci. 2000; 67(3):291-300. DOI: 10.1016/s0024-3205(00)00622-6. View

Gual P, Gremeaux T, Gonzalez T, Le Marchand-Brustel Y, Tanti J . MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia. 2003; 46(11):1532-42. DOI: 10.1007/s00125-003-1223-4. View

Steensberg A, Fischer C, Sacchetti M, Keller C, Osada T, Schjerling P . Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans. J Physiol. 2003; 548(Pt 2):631-8. PMC: 2342867. DOI: 10.1113/jphysiol.2002.032938. View

Tremblay F, Marette A . Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem. 2001; 276(41):38052-60. DOI: 10.1074/jbc.M106703200. View

10.

Klover P, Zimmers T, Koniaris L, Mooney R . Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes. 2003; 52(11):2784-9. DOI: 10.2337/diabetes.52.11.2784. View

11.

Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T . Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 1986; 324(6092):73-6. DOI: 10.1038/324073a0. View

12.

Lyngso D, Simonsen L, Bulow J . Metabolic effects of interleukin-6 in human splanchnic and adipose tissue. J Physiol. 2002; 543(Pt 1):379-86. PMC: 2290487. DOI: 10.1113/jphysiol.2002.021022. View

13.

Febbraio M, Steensberg A, Starkie R, McConell G, Kingwell B . Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise. Metabolism. 2003; 52(7):939-44. DOI: 10.1016/s0026-0495(03)00105-7. View

14.

Bastard J, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M . Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab. 2000; 85(9):3338-42. DOI: 10.1210/jcem.85.9.6839. View

15.

Hardin J, Kroeker K, Chung B, Gall D . Effect of proinflammatory interleukins on jejunal nutrient transport. Gut. 2000; 47(2):184-91. PMC: 1727997. DOI: 10.1136/gut.47.2.184. View

16.

Starkie R, Angus D, Rolland J, Hargreaves M, Febbraio M . Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans. J Physiol. 2000; 528(Pt 3):647-55. PMC: 2270161. DOI: 10.1111/j.1469-7793.2000.t01-1-00647.x. View

17.

DeFronzo R, Gunnarsson R, Bjorkman O, Olsson M, Wahren J . Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest. 1985; 76(1):149-55. PMC: 423730. DOI: 10.1172/JCI111938. View

18.

Shikhman A, Brinson D, Valbracht J, Lotz M . Cytokine regulation of facilitated glucose transport in human articular chondrocytes. J Immunol. 2001; 167(12):7001-8. DOI: 10.4049/jimmunol.167.12.7001. View

19.

Senn J, Klover P, Nowak I, Mooney R . Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes. 2002; 51(12):3391-9. DOI: 10.2337/diabetes.51.12.3391. View

20.

Heinrich P, Behrmann I, Muller-Newen G, Schaper F, Graeve L . Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J. 1998; 334 ( Pt 2):297-314. PMC: 1219691. DOI: 10.1042/bj3340297. View