A Potent Modifier of Liver Cancer Risk on Distal Mouse Chromosome 1: Linkage Analysis and Characterization of Congenic Lines

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 2004 Jul 9

PMID 15238534

Citations 20

Authors

Andrea Bilger

L Michelle Bennett

Reynaldo A Carabeo

Teresa A Chiaverotti

Cecily Dvorak

Kristin M Liss

Susan A Schadewald

Henry C Pitot

Norman R Drinkwater

Affiliations

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Abstract

The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoma development to distal chromosome 1, linked to the marker D1Mit33 with combined LOD(W) scores of approximately 5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1Mit17) and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P < 10(-11), in males; 3- to 4-fold, P < 10(-3), in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.

Citing Articles

In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling.

Romualdo G, Leroy K, Costa C, Prata G, Vanderborght B, Da Silva T Cancers (Basel). 2021; 13(21).

PMID: 34771745 PMC: 8582701. DOI: 10.3390/cancers13215583.

Experimental Models to Define the Genetic Predisposition to Liver Cancer.

Pascale R, Simile M, Peitta G, Seddaiu M, Feo F, Calvisi D Cancers (Basel). 2019; 11(10).

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Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics.

Guimaraes-Young A, Feddersen C, Dupuy A Front Oncol. 2019; 9:611.

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Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models.

Romualdo G, Prata G, Da Silva T, Fernandes A, Moreno F, Cogliati B PLoS One. 2018; 13(9):e0203879.

PMID: 30212575 PMC: 6136798. DOI: 10.1371/journal.pone.0203879.

DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status.

Herzig M, Zavadil J, Street K, Hildreth K, Drinkwater N, Reddick T Cancer Prev Res (Phila). 2015; 9(3):245-52.

PMID: 26667451 PMC: 4777656. DOI: 10.1158/1940-6207.CAPR-15-0251.

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