L-arginine-induced Experimental Pancreatitis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2004 Jul 9

PMID 15237423

Citations 48

Authors

Peter Hegyi

Zoltan Rakonczay Jr

Reka Sari

Csaba Gog

Janos Lonovics

Tamas Takacs

Laszlo Czako

Affiliations

Soon will be listed here.

Abstract

Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Therefore, it is very important to find good animal models to characterise the events of this severe disease. In 1984, Mizunuma et al. developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-arginine in rats. This non-invasive model is highly reproducible and produces selective, dose-dependent acinar cell necrosis. Not only is this a good model to study the pathomechanisms of acute necrotizing pancreatitis, but it is also excellent to observe and influence the time course changes of the disease. By writing this review we illuminate some new aspects of cell physiology and pathology of acute necrotizing pancreatitis. Unfortunately, the reviews about acute experimental pancreatitis usually did not discuss this model. Therefore, the aim of this manuscript was to summarise the observations and address some challenges for the future in L-arginine-induced pancreatitis.

Citing Articles

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Integrating metagenomics with metabolomics for gut microbiota and metabolites profiling in acute pancreatitis.

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L-Arginine-induced acute pancreatitis and its associated lung injury in rats: Down-regulation of TLR-4/MAPK-p38/JNK signaling pathway via extract EGb 761.

Mostafa R, Abdelrahmen S, Saleh D Iran J Basic Med Sci. 2024; 27(8):959-966.

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Sitagliptin ameliorates L-arginine-induced acute pancreatitis via modulating inflammatory cytokines expression and combating oxidative stress.

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