Effects of Radix Puerariae Flavones on Liver Lipid Metabolism in Ovariectomized Rats

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2004 Jun 29

PMID 15222048

Citations 16

Authors

Ji-Feng Wang

Yan-Xia Guo

Jan-Zhao Niu

Juan Liu

Ling-Qiao Wang

Pei-Heng Li

Affiliations

Soon will be listed here.

Abstract

Aim: To study the effects of Radix Puerariae flavones (RPF) on liver lipid metabolism in ovariectomized (OVX) rats.

Methods: Forty adult female Wistar rats were randomly divided into four groups: OVX group; sham-OVX group; OVX+estrogen group and OVX+RPF group. One week after operation rats of the first two groups were treated with physiological saline, rats of OVX+estrogen group with estrogen (1 mg/kg.b.w.) and rats of OVX+RPF group with RPF (100 mg/kg.b.w.), respectively for 5 weeks. After the rats were killed, their body weight, the weight of the abdominal fat and uterus were measured, and the levels of total cholesterol (TC) and triglyceride (TG) in liver homogenate were determined.

Results: Compared with the sham-OVX group, the body mass of the rats in OVX group was found increased significantly; more abdominal fat in store; TC and TG in liver increased and uterine became further atrophy. As a result, the RPF was found to have an inhibitive action on those changes of various degrees.

Conclusion: RPF has estrogen-like effect on lipid metabolism in liver and adipose tissue.

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