Cargo- and Compartment-selective Endocytic Scaffold Proteins

Overview

Journal Biochem J

Specialty Biochemistry

Date 2004 Jun 29

PMID 15219178

Citations 10

Authors

Iwona Szymkiewicz

Oleg Shupliakov

Ivan Dikic

Affiliations

Soon will be listed here.

Abstract

The endocytosis of membrane receptors is a complex and tightly controlled process that is essential for maintaining cellular homoeostasis. The removal of receptors from the cell surface can be constitutive or ligand-induced, and occurs in a clathrin-dependent or -independent manner. The recruitment of receptors into specialized membrane domains, the formation of vesicles and the trafficking of receptors together with their ligands within endocytic compartments are regulated by reversible protein modifications, and multiple protein-protein and protein-lipid interactions. Recent reports describe a variety of multidomain molecules that facilitate receptor endocytosis and function as platforms for the assembly of protein complexes. These scaffold proteins typically act in a cargo-specific manner, recognizing one or more receptor types, or function at the level of endocytic cellular microcompartments by controlling the movement of cargo molecules and linking endocytic machineries to signalling pathways. In the present review we summarize present knowledge on endocytic scaffold molecules and discuss their functions.

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References

Gaidarov I, Krupnick J, Falck J, Benovic J, Keen J . Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. EMBO J. 1999; 18(4):871-81. PMC: 1171180. DOI: 10.1093/emboj/18.4.871. View

Garcia C, Wilund K, Arca M, Zuliani G, Fellin R, Maioli M . Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science. 2001; 292(5520):1394-8. DOI: 10.1126/science.1060458. View

Berdnik D, Torok T, Gonzalez-Gaitan M, Knoblich J . The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell. 2002; 3(2):221-31. DOI: 10.1016/s1534-5807(02)00215-0. View

Laporte S, Miller W, Kim K, Caron M . beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin. J Biol Chem. 2002; 277(11):9247-54. DOI: 10.1074/jbc.M108490200. View

KOVOOR A, Celver J, Abdryashitov R, Chavkin C, Gurevich V . Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells. J Biol Chem. 1999; 274(11):6831-4. DOI: 10.1074/jbc.274.11.6831. View

Kamikura D, Cooper J . Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003; 17(22):2798-811. PMC: 280628. DOI: 10.1101/gad.1136103. View

Garrus J, von Schwedler U, Pornillos O, Morham S, Zavitz K, Wang H . Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell. 2001; 107(1):55-65. DOI: 10.1016/s0092-8674(01)00506-2. View

Katzmann D, Babst M, Emr S . Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell. 2001; 106(2):145-55. DOI: 10.1016/s0092-8674(01)00434-2. View

Merrifield C, Feldman M, Wan L, Almers W . Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits. Nat Cell Biol. 2002; 4(9):691-8. DOI: 10.1038/ncb837. View

10.

McDonald P, Lefkowitz R . Beta-Arrestins: new roles in regulating heptahelical receptors' functions. Cell Signal. 2001; 13(10):683-9. DOI: 10.1016/s0898-6568(01)00203-0. View

11.

Stamenova S, Dunn R, Adler A, Hicke L . The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167. J Biol Chem. 2004; 279(16):16017-25. DOI: 10.1074/jbc.M313479200. View

12.

Shupliakov O, Bloom O, Gustafsson J, Kjaerulff O, Low P, Tomilin N . Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton. Proc Natl Acad Sci U S A. 2002; 99(22):14476-81. PMC: 137908. DOI: 10.1073/pnas.212381799. View

13.

Dustin M, Olszowy M, Holdorf A, Li J, Bromley S, Desai N . A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell. 1998; 94(5):667-77. DOI: 10.1016/s0092-8674(00)81608-6. View

14.

Mishra S, Keyel P, Hawryluk M, Agostinelli N, Watkins S, Traub L . Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J. 2002; 21(18):4915-26. PMC: 126284. DOI: 10.1093/emboj/cdf487. View

15.

Chin L, Raynor M, Wei X, Chen H, Li L . Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J Biol Chem. 2000; 276(10):7069-78. DOI: 10.1074/jbc.M004129200. View

16.

Murthy V, De Camilli P . Cell biology of the presynaptic terminal. Annu Rev Neurosci. 2003; 26:701-28. DOI: 10.1146/annurev.neuro.26.041002.131445. View

17.

Holler D, Dikic I . Receptor endocytosis via ubiquitin-dependent and -independent pathways. Biochem Pharmacol. 2004; 67(6):1013-7. DOI: 10.1016/j.bcp.2004.01.003. View

18.

Hicke L, Dunn R . Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu Rev Cell Dev Biol. 2003; 19:141-72. DOI: 10.1146/annurev.cellbio.19.110701.154617. View

19.

Wiley H, Herbst J, Walsh B, Lauffenburger D, Rosenfeld M, Gill G . The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor. J Biol Chem. 1991; 266(17):11083-94. View

20.

Babst M, Katzmann D, Meerloo T, Emr S . Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell. 2002; 3(2):271-82. DOI: 10.1016/s1534-5807(02)00220-4. View