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Calcium Antagonists: A New Class of Therapeutic Agents

Overview
Journal Cardiovasc Dis
Date 1981 Sep 1
PMID 15216199
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Abstract

A new class of therapeutic agents, sharing inhibition of the slow calcium channel, will soon be available to the American patient. Selective action of these agents upon the atrioventricular node, the smooth muscle of coronary and peripheral arteries, and the contractility of cardiac muscle opens new vistas in cardiovascular pharmacology. Early release of these agents by the Federal Drug Administration for general use is urged, based upon the already wide and successful experience in the European and South American continents.

References
1.
Henry P . Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. Am J Cardiol. 1980; 46(6):1047-58. DOI: 10.1016/0002-9149(80)90366-5. View

2.
Reimer K, Lowe J, Jennings R . Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs. Circulation. 1977; 55(4):581-7. DOI: 10.1161/01.cir.55.4.581. View

3.
Spurrell R, Krikler D, Sowton E . Effects of verapamil on electrophysiological properties of anomalous atrioventricular connexion in Wolff-Parkinson-White syndrome. Br Heart J. 1974; 36(3):256-64. PMC: 458827. DOI: 10.1136/hrt.36.3.256. View

4.
Antman E, Stone P, Muller J, Braunwald E . Calcium channel blocking agents in the treatment of cardiovascular disorders. Part I: Basic and clinical electrophysiologic effects. Ann Intern Med. 1980; 93(6):875-85. DOI: 10.7326/0003-4819-93-6-875. View

5.
Rosing D, Kent K, Maron B, Epstein S . Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. II. Effects on exercise capacity and symptomatic status. Circulation. 1979; 60(6):1208-13. DOI: 10.1161/01.cir.60.6.1208. View