Heparan Sulphate Identified on Human Erythrocytes: a Plasmodium Falciparum Receptor

Overview

Journal Biochem J

Specialty Biochemistry

Date 2004 Jun 24

PMID 15209561

Citations 32

Authors

Anna M Vogt

Gerhard Winter

Mats Wahlgren

Dorothe Spillmann

Affiliations

Soon will be listed here.

Abstract

HS (heparan sulphate) has hitherto not been found on human red blood cells (RBCs, erythrocytes). However, malarial-parasite (Plasmodium falciparum)-infected RBCs adhere to uninfected RBCs via HS-like receptors. In the present paper we demonstrate that human RBCs carry epitopes for an anti-HS antibody. Glycans isolated from RBC membranes reacted to HS-specific degradations and adhered to an HS-binding malaria antigen. Additionally, an HS core protein was identified. This suggests that HS is present on human RBCs.

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