Newborn Screening for Congenital Infectious Diseases

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2004 Jun 23

PMID 15207059

Citations 28

Authors

Eurico Camargo Neto

Roselia Rubin

Jacqueline Schulte

Roberto Giugliani

Affiliations

Soon will be listed here.

Abstract

To estimate the prevalence of congenital toxoplasmosis, Chagas disease, cytomegalovirus, and rubella, blood samples on dried blood spot (DBS) from neonates (day 3-20 of life) were screened for immunoglobulin (Ig) M against Toxoplasma gondii, cytomegalovirus, rubella virus, and IgG against Trypanosoma cruzi by methods used for serum and adapted for use with DBS. Positive samples were further analyzed for IgM and IgG in serum from neonates and mothers. DBS samples from 364,130 neonates were tested for Toxoplasma gondii-specific IgM, and 15,873 neonates were also tested for IgM against cytomegalovirus and rubella virus and for Trypanosoma cruzi-specific IgG. A total of 195 were diagnosed with congenital toxoplasmosis, 16 with cytomegalovirus, and 11 with congenital rubella. One newborn had a confirmed result for Chagas disease, and 21 mothers had positive serum antibodies. These results suggest that infectious diseases should be considered for future inclusion in programs for newborn screening of metabolic diseases in disease-endemic areas.

Citing Articles

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Arboviruses as an unappreciated cause of non-malarial acute febrile illness in the Dschang Health District of western Cameroon.

Ali I, Tchuenkam V, Colton M, Stittleburg V, Mitchell C, Gaither C PLoS Negl Trop Dis. 2022; 16(10):e0010790.

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Rapid method towards proteomic analysis of dried blood spots by MALDI mass spectrometry.

Samenuk G, Kelley A, Perry G, Bach S Clin Mass Spectrom. 2021; 12:30-36.

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Congenital Toxoplasmosis: Findings in Fetal MRI.

Lazarte-Rantes C, Rodriguez-Anccasi R, Rivas-Campos C, Silva E Cureus. 2021; 13(8):e16894.

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Congenital toxoplasmosis in humans: an update of worldwide rate of congenital infections.

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PMID: 34254575 PMC: 11010219. DOI: 10.1017/S0031182021001013.

References

Russomando G, de Tomassone M, De Guillen I, Acosta N, Vera N, Almiron M . Treatment of congenital Chagas' disease diagnosed and followed up by the polymerase chain reaction. Am J Trop Med Hyg. 1998; 59(3):487-91. DOI: 10.4269/ajtmh.1998.59.487. View

Frey T . Neurological aspects of rubella virus infection. Intervirology. 1997; 40(2-3):167-75. DOI: 10.1159/000150543. View

Lebech M, Andersen O, Christensen N, Hertel J, Nielsen H, Peitersen B . Feasibility of neonatal screening for toxoplasma infection in the absence of prenatal treatment. Danish Congenital Toxoplasmosis Study Group . Lancet. 1999; 353(9167):1834-7. DOI: 10.1016/s0140-6736(98)11281-3. View

Cutts F, Vynnycky E . Modelling the incidence of congenital rubella syndrome in developing countries. Int J Epidemiol. 2000; 28(6):1176-84. DOI: 10.1093/ije/28.6.1176. View

Basombrio M, NASSER J, Segura M, Marco D, Sanchez Negrette O, Padilla M . [The transmission de Chagas disease in Salta and the detection of congenital cases]. Medicina (B Aires). 2000; 59 Suppl 2:143-6. View

Salvatella R, Rosa R, Gonzalez M, Basmadjian Y, Combol A, Benavidez U . [Seroprevalence of T. cruzi infection in 6- and 12- year-old school children from three Uruguayan endemic departments]. Bol Chil Parasitol. 2000; 54(3-4):51-6. View

Contreras S, Fernandez M, Aguero F, Desse Desse J, Orduna T, Martino O . [Congenital Chagas-Mazza disease in Salta, Argentina]. Rev Soc Bras Med Trop. 2000; 32(6):633-6. DOI: 10.1590/s0037-86821999000600004. View

Neto E, Anele E, Rubim R, Brites A, Schulte J, Becker D . High prevalence of congenital toxoplasmosis in Brazil estimated in a 3-year prospective neonatal screening study. Int J Epidemiol. 2000; 29(5):941-7. DOI: 10.1093/ije/29.5.941. View

Boppana S, Rivera L, Fowler K, Mach M, Britt W . Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. N Engl J Med. 2001; 344(18):1366-71. DOI: 10.1056/NEJM200105033441804. View

10.

Trincado D, Rawlinson W . Congenital and perinatal infections with cytomegalovirus. J Paediatr Child Health. 2001; 37(2):187-92. DOI: 10.1046/j.1440-1754.2001.00645.x. View

11.

Jones J, Lopez A, Wilson M, Schulkin J, Gibbs R . Congenital toxoplasmosis: a review. Obstet Gynecol Surv. 2001; 56(5):296-305. DOI: 10.1097/00006254-200105000-00025. View

12.

Fowler K, Dahle A, Boppana S, Pass R . Newborn hearing screening: will children with hearing loss caused by congenital cytomegalovirus infection be missed?. J Pediatr. 1999; 135(1):60-4. DOI: 10.1016/s0022-3476(99)70328-8. View

13.

Pays J . [Human American trypanosomiasis 90 years after its discovery by Carlos Chagas. II--Clinical aspects, physiopathology, diagnosis and treatment]. Med Trop (Mars). 1999; 59(1):79-94. View

14.

Jaisson-Hot I, Wallon M, Al Kurdi M, Thulliez P, Kahi S, Cozon G . [Congenital toxoplasmosis. Transitory negative serology]. Presse Med. 2001; 30(20):1001-4. View

15.

Ambroise-Thomas P, Schweitzer M, Pinon J, Thiebaugeorges O . [Prevention of congenital toxoplasmosis in France. Risk assessment. Results and perspectives of prenatal screening and newborn follow up]. Bull Acad Natl Med. 2001; 185(4):665-83; discussion 684-8. View

16.

Peckham C, Tookey P, Logan S, Giaquinto C . Screening options for prevention of congenital cytomegalovirus infection. J Med Screen. 2001; 8(3):119-24. DOI: 10.1136/jms.8.3.119. View

17.

Gras L, Gilbert R, Ades A, Dunn D . Effect of prenatal treatment on the risk of intracranial and ocular lesions in children with congenital toxoplasmosis. Int J Epidemiol. 2002; 30(6):1309-13. DOI: 10.1093/ije/30.6.1309. View

18.

Damato E, Winnen C . Cytomegalovirus infection: perinatal implications. J Obstet Gynecol Neonatal Nurs. 2002; 31(1):86-92. DOI: 10.1111/j.1552-6909.2002.tb00026.x. View

19.

Weng Y, Chu S, Lien R, Chou Y, Lin T . Clinical experience with ganciclovir and anti-cytomegalovirus immunoglobulin treatment for a severe case of congenital cytomegalovirus infection. Chang Gung Med J. 2003; 26(2):128-32. View

20.

Ushida M, Katow S, Furukawa S . Congenital rubella syndrome due to infection after maternal antibody conversion with vaccine. Jpn J Infect Dis. 2003; 56(2):68-9. View