Reactive Oxygen Species (ROS) Generation Inhibited by Aporphine and Phenanthrene Alkaloids Semi-synthesized from Natural Boldine

Overview

Journal Chem Pharm Bull (Tokyo)

Specialties Chemistry
Pharmacology

Date 2004 Jun 10

PMID 15187389

Citations 6

Authors

Lara Milian

Rossana Estelles

Belen Abarca

Rafael Ballesteros

Maria Jesus Sanz

Maria Amparo Blazquez

Affiliations

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Abstract

Four phenanthrene and one aporphine alkaloids semi-synthesized from boldine were evaluated for their inhibitory effect on reactive oxygen species (ROS) generation. ROS generation by neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine was inhibited in a concentration dependent manner. Alkaloids exerted similar inhibitory effect in the hypoxanthine-xanthine oxidase system than in stimulated neutrophils, which could be attributed to a direct ROS scavenging activity. None of the alkaloids assayed had any effect on xanthine oxidase activity. Therefore the synthesized alkaloids might constitute an alternative therapy in inflammation disorders in which ROS generation is involved.

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