CPAP-therapy Effectively Lowers Serum Homocysteine in Obstructive Sleep Apnea Syndrome

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2004 May 29

PMID 15168215

Citations 17

Authors

W Jordan

C Berger

S Cohrs

A Rodenbeck

G Mayer

P D Niedmann

N von Ahsen

E Ruther

J Kornhuber

S Bleich

Affiliations

Soon will be listed here.

Abstract

Assessment of serum total homocysteine (tHcy) in patients with obstructive sleep apnea (OSA) syndrome is highly relevant since both are strongly associated with stroke and cognitive dysfunction. Seven of 16 untreated OSA patients showed tHcy levels exceeding 11.7 micromol/l. The circadian pattern of serum tHcy in untreated and treated patients (p < 0.001) implied a diagnostic impact of blood sampling time. Treatment with continuous positive airway pressure (CPAP) effectively lowered tHcy levels in patients by about 30% (p < 0.005) and thus probably the (hyper)homocysteinemia-related cognitive dysfunction and the risk for cardio-/cerebrovascular diseases.

Citing Articles

Association between elevated homocysteine levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis.

He J, Zhou H, Xiong J, Huang Y, Huang N, Jiang J Front Endocrinol (Lausanne). 2024; 15:1378293.

PMID: 38887264 PMC: 11180825. DOI: 10.3389/fendo.2024.1378293.

Homocysteine as a predictor of apnea-hypopnea index in obstructive sleep apnea: a longitudinal epidemiological study (EPISONO).

Cavalcante-Silva V, Morelhao P, Fernandes G, DAlmeida V, Tufik S, Andersen M Eur Arch Otorhinolaryngol. 2024; 281(6):3237-3243.

PMID: 38568296 DOI: 10.1007/s00405-024-08614-z.

Obstructive sleep apnea affects cognition: dual effects of intermittent hypoxia on neurons.

He Y, Dong N, Wang X, Lv R, Yu Q, Yue H Sleep Breath. 2024; 28(3):1051-1065.

PMID: 38308748 DOI: 10.1007/s11325-024-03001-8.

Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea.

Meliante P, Zoccali F, Cascone F, Di Stefano V, Greco A, de Vincentiis M Int J Mol Sci. 2023; 24(6).

PMID: 36982552 PMC: 10058074. DOI: 10.3390/ijms24065478.

Chromatography/Mass Spectrometry-Based Biomarkers in the Field of Obstructive Sleep Apnea.

Xu H, Zheng X, Jia W, Yin S Medicine (Baltimore). 2015; 94(40):e1541.

PMID: 26448002 PMC: 4616745. DOI: 10.1097/MD.0000000000001541.