The MRNA Cap-binding Protein EIF4E in Post-transcriptional Gene Expression

Overview

Journal Nat Struct Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2004 May 28

PMID 15164008

Citations 114

Authors

Tobias von der Haar

John D Gross

Gerhard Wagner

John E G McCarthy

Affiliations

Soon will be listed here.

Abstract

Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.

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