Traffic COPs and the Formation of Vesicle Coats

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 1996 Dec 1

PMID 15157504

Citations 33

Authors

S Y Bednarek

L Orci

R Schekman

Affiliations

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Abstract

Forward and retrograde trafficking of secretory proteins between the endoplasmic reticulum and the Golgi apparatus is driven by two biochemically distinct vesicle coats, COPI and COPII. Assembly of the coats on their target membranes is thought to provide the driving force for membrane deformation and the selective packaging of cargo and targeting molecules into nascent transport vesicles. This review describes our current knowledge on these issues and discusses how the two coats may be differentially targeted and assembled to achieve protein sorting and transport within the early secretory pathway.

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