PH, EF-1alpha and the Cytoskeleton

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 1996 May 1

PMID 15157465

Citations 22

Authors

G Liu

B T Edmonds

J Condeelis

Affiliations

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Abstract

One of the unexpected cellular components found interacting with the cytoskeleton is elongation factor 1 alpha (EF-1alpha). How this interaction is regulated is not clear, but pH may be a potent regulator. Interestingly, pH also regulates the amount of protein translation occurring in many cell systems. In this paper, the authors suggest that sequestration of EF-1alpha in the cytoskeleton may play a key role in regulating the spatial distribution of macromolecular assembly in a way that is dependent on cytoplasmic pH.

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