About GATA3, HNF3A, and XBP1, Three Genes Co-expressed with the Oestrogen Receptor-alpha Gene (ESR1) in Breast Cancer

Overview

Journal Mol Cell Endocrinol

Specialties Cell Biology
Endocrinology
Molecular Biology

Date 2004 May 20

PMID 15149721

Citations 65

Authors

M Lacroix

G Leclercq

Affiliations

Soon will be listed here.

Abstract

In breast tumours and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are expressed in close association with the oestrogen receptor-alpha (ER-alpha) gene, ESR1. Three of them, GATA3, HNF3A (also known as FOXA1), and XBP1 encode transcription factors. Here, we present these factors and we discuss their potential involvement in the ER-alpha-mediated actions in BCC. We notably show the relations that exist, or that might exist, between these factors and the oestrogen-inducible trefoil factor TFF1.

Citing Articles

Beyond Hormone Receptors: liquid biopsy tools to unveil new clinical meanings and empower therapeutic decision-making in Luminal-like metastatic breast cancer.

Pasto B, Vida R, Dri A, Foffano L, Della Rossa S, Gerratana L Breast. 2024; 79:103859.

PMID: 39708442 PMC: 11872398. DOI: 10.1016/j.breast.2024.103859.

Role of Fork-Head Box Genes in Breast Cancer: From Drug Resistance to Therapeutic Targets.

Sadaf , Hazazi A, Alkhalil S, Alsaiari A, Gharib A, Alhuthali H Biomedicines. 2023; 11(8).

PMID: 37626655 PMC: 10452497. DOI: 10.3390/biomedicines11082159.

Genetic architecture of mammographic density as a risk factor for breast cancer: a systematic review.

Shamshiri A, Alidoust M, Hemmati Nokandei M, Pasdar A, Afzaljavan F Clin Transl Oncol. 2023; 25(6):1729-1747.

PMID: 36639603 DOI: 10.1007/s12094-022-03071-8.

Knockdown of FOXA1 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the ERK1/2 signalling pathway.

Li L, Wang Y, Wang Z, Xue D, Dai C, Gao X Stem Cell Res Ther. 2022; 13(1):456.

PMID: 36064451 PMC: 9446550. DOI: 10.1186/s13287-022-03133-2.

X-box binding protein 1 (XBP1): a potential role in chemotherapy response, clinical pathologic features, non-inflamed tumour microenvironment for breast cancer.

Zhu Z, Zhan H, Sun A, Huang H, Chen B, Zhang F Biosci Rep. 2022; 42(6).

PMID: 35543228 PMC: 9202509. DOI: 10.1042/BSR20220225.