Bone and Fat: Old Questions, New Insights

Overview

Journal Endocrine

Specialty Endocrinology

Date 2004 May 18

PMID 15146099

Citations 44

Authors

Jeffrey M Gimble

Mark E Nuttall

Affiliations

Soon will be listed here.

Abstract

Until recently, adipose tissue was considered to serve only as a triglyceride reservoir and was relegated to a passive endocrine role. With the discovery of leptin and other adipokines, adipose tissue is now recognized as an active participant in systemic metabolism. This review focuses on the complex relationship existing between adipose tissue and bone metabolism and differentiation. It explores the paradigms that have shaped the past decade's research and what these findings forecast for the future. Particular attention is given to the multipotent adult stem cell populations that reside within bone and fat. These adult stem cells have critical importance to the emerging field of tissue engineering and regenerative medicine.

Citing Articles

The Implications of Bone Marrow Adipose Tissue on Inflammaging.

Aaron N, Costa S, Rosen C, Qiang L Front Endocrinol (Lausanne). 2022; 13:853765.

PMID: 35360075 PMC: 8962663. DOI: 10.3389/fendo.2022.853765.

Bone-Muscle Mutual Interactions.

Lara-Castillo N, Johnson M Curr Osteoporos Rep. 2020; 18(4):408-421.

PMID: 32519283 PMC: 8059358. DOI: 10.1007/s11914-020-00602-6.

Human Bone Marrow Adipose Tissue is a Metabolically Active and Insulin-Sensitive Distinct Fat Depot.

Pham T, Ivaska K, Hannukainen J, Virtanen K, Lidell M, Enerback S J Clin Endocrinol Metab. 2020; 105(7).

PMID: 32311037 PMC: 7247553. DOI: 10.1210/clinem/dgaa216.

Conditioned Medium Enhances Osteogenic Differentiation of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells.

Zhong S, He X, Li Y, Lou X Tissue Eng Regen Med. 2019; 16(2):141-150.

PMID: 30989041 PMC: 6439034. DOI: 10.1007/s13770-018-0173-3.

The Effect of Antidepressants on Mesenchymal Stem Cell Differentiation.

Kruk J, Bermeo S, Skarratt K, Fuller S, Duque G J Bone Metab. 2018; 25(1):43-51.

PMID: 29564305 PMC: 5854822. DOI: 10.11005/jbm.2018.25.1.43.

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