» Articles » PMID: 15142857

Sympathetic Innervation of White Adipose Tissue and Its Regulation of Fat Cell Number

Overview
Specialty Physiology
Date 2004 May 15
PMID 15142857
Citations 93
Authors
Affiliations
Soon will be listed here.
Abstract

White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS), and the central origins of this innervation have been demonstrated for inguinal and epididymal WAT (iWAT and eWAT, respectively) using a viral transneuronal tract tracer, the pseudorabies virus (PRV). Although the more established role of this sympathetic innervation of WAT is as a major stimulator of lipid mobilization, this innervation also inhibits WAT fat cell number (FCN); thus, local denervation of WAT leads to marked increases in WAT mass and FCN. The purpose of this study was to extend our understanding of the SNS regulation of FCN using neuroanatomical and functional analyses. Therefore, we injected PRV into retroperitoneal WAT (rWAT) to compare the SNS outflow to this pad from what already is known for iWAT and eWAT. In addition, we tested the ability of local unilateral denervation of rWAT or iWAT to promote increases in WAT mass and FCN vs. their contralateral neurally intact counterparts. Although the overall pattern of innervation was more similar than different for rWAT vs. iWAT or eWAT, its SNS outflow appeared to involve more neurons in the suprachiasmatic and solitary tract nuclei. Denervation produced significant increases in WAT mass and FCN for both iWAT and rWAT, but FCN was increased significantly more in iWAT than in rWAT. These data suggest differences in origins of the sympathetic outflow to WAT and functional differences in the WAT SNS innervation that could contribute to the differential propensity for fat cell proliferation across WAT depots in vivo.

Citing Articles

Spinal afferent neurons: emerging regulators of energy balance and metabolism.

Jarrah M, Tasabehji D, Fraer A, Mokadem M Front Mol Neurosci. 2024; 17:1479876.

PMID: 39582948 PMC: 11583444. DOI: 10.3389/fnmol.2024.1479876.


Interplay between the brain and adipose tissue: a metabolic conversation.

Diaz-Castro F, Morselli E, Claret M EMBO Rep. 2024; 25(12):5277-5293.

PMID: 39558137 PMC: 11624209. DOI: 10.1038/s44319-024-00321-4.


An atlas of brain-bone sympathetic neural circuits in mice.

Ryu V, Gumerova A, Witztum R, Korkmaz F, Cullen L, Kannangara H Elife. 2024; 13.

PMID: 38963696 PMC: 11245306. DOI: 10.7554/eLife.95727.


Long-duration leptin transgene expression in dorsal vagal complex does not alter bone parameters in female Sprague Dawley rats.

Turner R, Branscum A, Iwaniec U Bone Rep. 2024; 21:101769.

PMID: 38706522 PMC: 11067478. DOI: 10.1016/j.bonr.2024.101769.


α2δ1-mediated maladaptive sensory plasticity disrupts adipose tissue homeostasis following spinal cord injury.

Roy D, Dion E, Sepeda J, Peng J, Lingam S, Townsend K Cell Rep Med. 2024; 5(5):101525.

PMID: 38663398 PMC: 11148638. DOI: 10.1016/j.xcrm.2024.101525.