Melissa Officinalis L. Essential Oil: Antitumoral and Antioxidant Activities

Overview

Journal J Pharm Pharmacol

Publisher Oxford University Press

Specialties Pharmacology
Pharmacy

Date 2004 May 15

PMID 15142347

Citations 37

Authors

Allyne Carvalho de Sousa

Daniela Sales Alviano

Arie Fitzgerald Blank

Pericles Barreto Alves

Celuta Sales Alviano

Cerli Rocha Gattass

Affiliations

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Abstract

Melissa officinalis L (lemon balm) is a traditional herbal medicine used widely as a mild sedative, spasmolytic and antibacterial agent. This paper focuses on the analysis of the chemical composition and the biological activities of M. officinalis essential oil obtained under controlled harvesting and drying conditions. An in-vitro cytotoxicity assay using MTT indicated that this oil was very effective against a series of human cancer cell lines (A549, MCF-7, Caco-2, HL-60, K562) and a mouse cell line (B16F10). This oil possessed antioxidant activity, as evidenced by reduction of 1,1-diphenyl-2-picryl-hydrazyl (DPPH). These results pointed to the potential use of M. officinalis essential oil as an antitumoral agent.

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